Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy

Abstract We aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010–2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed def...

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Autores principales:	Yu-Chieh Ho, Yuan-Chun Lai, Hsuan-Yu Lin, Ming-Hui Ko, Sheng-Hung Wang, Shan-Jun Yang, Po-Ju Lin, Tsai-Wei Chou, Li-Chung Hung, Chia-Chun Huang, Tung-Hao Chang, Jhen-Bin Lin, Jin-Ching Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c45f1c6dd95b46cdae27304ef6c20604
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spelling	oai:doaj.org-article:c45f1c6dd95b46cdae27304ef6c206042021-12-02T17:04:06ZLow cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy10.1038/s41598-021-86019-22045-2322https://doaj.org/article/c45f1c6dd95b46cdae27304ef6c206042021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86019-2https://doaj.org/toc/2045-2322Abstract We aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010–2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed definitive CCRT. Patients' clinical, dosimetric, and hematological data, including absolute neutrophil count, absolute lymphocyte count, and neutrophil-to-lymphocyte ratio (NLR), at baseline, during, and post-CCRT were analyzed. Cox proportional hazards were calculated to identify potential risk factors for overall survival (OS). Median OS was 13 months (95% confidence interval [CI]: 10.38–15.63). Univariate analysis revealed that male sex, poor performance status, advanced nodal stage, higher percentage of heart receiving 10 Gy (heart V10), and higher NLR (baseline and follow-up) were significantly associated with worse OS. In multivariate analysis, performance status (ECOG 0 & 1 vs. 2; hazard ratio [HR] 3.12, 95% CI 1.30–7.48), heart V10 (> 84% vs. ≤ 84%; HR 2.24, 95% CI 1.26–3.95), baseline NLR (> 3.56 vs. ≤ 3.56; HR 2.36, 95% CI 1.39–4.00), and follow-up NLR (> 7.4 vs. ≤ 7.4; HR 1.95, 95% CI 1.12–3.41) correlated with worse OS. Volume of low cardiac dose and NLR (baseline and follow-up) were associated with worse patient survival.Yu-Chieh HoYuan-Chun LaiHsuan-Yu LinMing-Hui KoSheng-Hung WangShan-Jun YangPo-Ju LinTsai-Wei ChouLi-Chung HungChia-Chun HuangTung-Hao ChangJhen-Bin LinJin-Ching LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Chieh Ho Yuan-Chun Lai Hsuan-Yu Lin Ming-Hui Ko Sheng-Hung Wang Shan-Jun Yang Po-Ju Lin Tsai-Wei Chou Li-Chung Hung Chia-Chun Huang Tung-Hao Chang Jhen-Bin Lin Jin-Ching Lin Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
description	Abstract We aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010–2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed definitive CCRT. Patients' clinical, dosimetric, and hematological data, including absolute neutrophil count, absolute lymphocyte count, and neutrophil-to-lymphocyte ratio (NLR), at baseline, during, and post-CCRT were analyzed. Cox proportional hazards were calculated to identify potential risk factors for overall survival (OS). Median OS was 13 months (95% confidence interval [CI]: 10.38–15.63). Univariate analysis revealed that male sex, poor performance status, advanced nodal stage, higher percentage of heart receiving 10 Gy (heart V10), and higher NLR (baseline and follow-up) were significantly associated with worse OS. In multivariate analysis, performance status (ECOG 0 & 1 vs. 2; hazard ratio [HR] 3.12, 95% CI 1.30–7.48), heart V10 (> 84% vs. ≤ 84%; HR 2.24, 95% CI 1.26–3.95), baseline NLR (> 3.56 vs. ≤ 3.56; HR 2.36, 95% CI 1.39–4.00), and follow-up NLR (> 7.4 vs. ≤ 7.4; HR 1.95, 95% CI 1.12–3.41) correlated with worse OS. Volume of low cardiac dose and NLR (baseline and follow-up) were associated with worse patient survival.
format	article
author	Yu-Chieh Ho Yuan-Chun Lai Hsuan-Yu Lin Ming-Hui Ko Sheng-Hung Wang Shan-Jun Yang Po-Ju Lin Tsai-Wei Chou Li-Chung Hung Chia-Chun Huang Tung-Hao Chang Jhen-Bin Lin Jin-Ching Lin
author_facet	Yu-Chieh Ho Yuan-Chun Lai Hsuan-Yu Lin Ming-Hui Ko Sheng-Hung Wang Shan-Jun Yang Po-Ju Lin Tsai-Wei Chou Li-Chung Hung Chia-Chun Huang Tung-Hao Chang Jhen-Bin Lin Jin-Ching Lin
author_sort	Yu-Chieh Ho
title	Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
title_short	Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
title_full	Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
title_fullStr	Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
title_full_unstemmed	Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
title_sort	low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c45f1c6dd95b46cdae27304ef6c20604
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Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy

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