Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils

The human voltage-gated proton channel (hHv1) maintains intracellular pH and membrane potential in sperm and neutrophils. Here, the authors show that albumin activates hHv1, by binding to the channel voltage sensor domains to enhance open probability and increases proton current, and that activation...

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Autores principales:	Ruiming Zhao, Hui Dai, Rodolfo J. Arias, Gerardo A. De Blas, Gerardo Orta, Martín A. Pavarotti, Rong Shen, Eduardo Perozo, Luis S. Mayorga, Alberto Darszon, Steve A. N. Goldstein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c46008eddc1543f7b537b4b7900693ee
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spelling	oai:doaj.org-article:c46008eddc1543f7b537b4b7900693ee2021-12-02T16:06:03ZDirect activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils10.1038/s41467-021-24145-12041-1723https://doaj.org/article/c46008eddc1543f7b537b4b7900693ee2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24145-1https://doaj.org/toc/2041-1723The human voltage-gated proton channel (hHv1) maintains intracellular pH and membrane potential in sperm and neutrophils. Here, the authors show that albumin activates hHv1, by binding to the channel voltage sensor domains to enhance open probability and increases proton current, and that activation is required to trigger sperm to allow oocyte fertilization and to sustain production and release of immune inflammatory mediators during the neutrophil respiratory burst.Ruiming ZhaoHui DaiRodolfo J. AriasGerardo A. De BlasGerardo OrtaMartín A. PavarottiRong ShenEduardo PerozoLuis S. MayorgaAlberto DarszonSteve A. N. GoldsteinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruiming Zhao Hui Dai Rodolfo J. Arias Gerardo A. De Blas Gerardo Orta Martín A. Pavarotti Rong Shen Eduardo Perozo Luis S. Mayorga Alberto Darszon Steve A. N. Goldstein Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
description	The human voltage-gated proton channel (hHv1) maintains intracellular pH and membrane potential in sperm and neutrophils. Here, the authors show that albumin activates hHv1, by binding to the channel voltage sensor domains to enhance open probability and increases proton current, and that activation is required to trigger sperm to allow oocyte fertilization and to sustain production and release of immune inflammatory mediators during the neutrophil respiratory burst.
format	article
author	Ruiming Zhao Hui Dai Rodolfo J. Arias Gerardo A. De Blas Gerardo Orta Martín A. Pavarotti Rong Shen Eduardo Perozo Luis S. Mayorga Alberto Darszon Steve A. N. Goldstein
author_facet	Ruiming Zhao Hui Dai Rodolfo J. Arias Gerardo A. De Blas Gerardo Orta Martín A. Pavarotti Rong Shen Eduardo Perozo Luis S. Mayorga Alberto Darszon Steve A. N. Goldstein
author_sort	Ruiming Zhao
title	Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
title_short	Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
title_full	Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
title_fullStr	Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
title_full_unstemmed	Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
title_sort	direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c46008eddc1543f7b537b4b7900693ee
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Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils

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