Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice

Immunization with desmoglein 3 induces non-pathogenic autoantibodies in mice

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<h4>Background</h4> Pemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by the development of autoantibodies targeting desmoglein (Dsg) 3, but also against Dsg1 in mucocutaneous disease. Given that existing PV animal models only recapitulate aspects of the disea...

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Main Authors: Katharina Boch, Sören Dräger, Detlef Zillikens, Christoph Hudemann, Christoph M. Hammers, Sabrina Patzelt, Enno Schmidt, Ewan A. Langan, Rüdiger Eming, Ralf J. Ludwig, Katja Bieber
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2021
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/c460bbe3c9964bc3b4f88249fe8bfd15
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