Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits

This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four group...

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Autores principales:	Zhang Jing, Yao Ming-yan, Zhang Guo-rui, Chen Xian-ru, Liu Qi, Guo Yifang, Jia Xin-wei
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	atherosclerosis r-amlodipine s-amlodipine vecs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c463b738ef0b4e12841ce9b8109123f6
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spelling	oai:doaj.org-article:c463b738ef0b4e12841ce9b8109123f62021-12-05T14:10:41ZEffects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits2391-541210.1515/biol-2021-0077https://doaj.org/article/c463b738ef0b4e12841ce9b8109123f62021-09-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0077https://doaj.org/toc/2391-5412This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2.5 mg/kg/day R-amlodipine, and group-D rabbits were fed a high-fat diet plus 5 mg/kg/day racemic amlodipine. Different enantiomers of amlodipine did not influence lipid profiles and serum level of eNOS in the rabbit atherosclerosis model but decreased ET-1 expression to some extent. The serum NO and iNOS levels in the drug intervention groups were significantly reduced. No significant differences in the rabbits’ body weights were observed. At the 4th and 8th weeks, the serum lipid profiles significantly increased in high cholesterol diet groups. The serum ET-1 level was significantly increased in each group of rabbits at the 8th week. Both S-amlodipine and R-amlodipine may protect the endothelium by reducing the serum ET-1 level, downregulating iNOS expression.Zhang JingYao Ming-yanZhang Guo-ruiChen Xian-ruLiu QiGuo YifangJia Xin-weiDe Gruyterarticleatherosclerosisr-amlodipines-amlodipinevecsBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 899-908 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atherosclerosis r-amlodipine s-amlodipine vecs Biology (General) QH301-705.5
spellingShingle	atherosclerosis r-amlodipine s-amlodipine vecs Biology (General) QH301-705.5 Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
description	This research aimed to describe the functions of vascular endothelial cells (VECs) in protecting target organs and the anti-atherosclerotic effects of different enantiomers of amlodipine on a rabbit model of atherosclerosis. Thirty male New Zealand white rabbits were randomly allocated to four groups (nA = 9, nB = 7, nC = 7, and nD = 7 rabbits): rabbits in group-A (control group) were fed a high-fat diet, group-B rabbits were fed a high-fat diet plus 2.5 mg/kg/day S-amlodipine, group-C rabbits were fed a high-fat diet plus 2.5 mg/kg/day R-amlodipine, and group-D rabbits were fed a high-fat diet plus 5 mg/kg/day racemic amlodipine. Different enantiomers of amlodipine did not influence lipid profiles and serum level of eNOS in the rabbit atherosclerosis model but decreased ET-1 expression to some extent. The serum NO and iNOS levels in the drug intervention groups were significantly reduced. No significant differences in the rabbits’ body weights were observed. At the 4th and 8th weeks, the serum lipid profiles significantly increased in high cholesterol diet groups. The serum ET-1 level was significantly increased in each group of rabbits at the 8th week. Both S-amlodipine and R-amlodipine may protect the endothelium by reducing the serum ET-1 level, downregulating iNOS expression.
format	article
author	Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei
author_facet	Zhang Jing Yao Ming-yan Zhang Guo-rui Chen Xian-ru Liu Qi Guo Yifang Jia Xin-wei
author_sort	Zhang Jing
title	Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
title_short	Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
title_full	Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
title_fullStr	Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
title_full_unstemmed	Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
title_sort	effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/c463b738ef0b4e12841ce9b8109123f6
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_version_	1718371865071714304

Effects of different enantiomers of amlodipine on lipid profiles and vasomotor factors in atherosclerotic rabbits

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