STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA

Abstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL...

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Autores principales:	O. V. Smirnova, A. A. Savchenko, V. T. Manchuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunity non-lymphoblastic leukemia lymphoblastic leukemia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c4655c09d0ca4de6975decea35ebf714
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spelling	oai:doaj.org-article:c4655c09d0ca4de6975decea35ebf7142021-11-18T08:03:39ZSTAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA1563-06252313-741X10.15789/1563-0625-2007-4-5-447-456https://doaj.org/article/c4655c09d0ca4de6975decea35ebf7142014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/202https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL they were detected in the state of clinical remission. In cases of ANLL, T cell immunodeficiency did develop in crisis and remission, whereas combined T- and B-cell immunodeficiency occurs during relapse of ANLL. T cell immunodeficiency was found to develop at all stages of ALL. These changes and differences may characterize specific immunopathogenetic aspects of development and progression of ANLL and acute ALL.O. V. SmirnovaA. A. SavchenkoV. T. ManchukSPb RAACIarticleimmunitynon-lymphoblastic leukemialymphoblastic leukemiaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 447-456 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunity non-lymphoblastic leukemia lymphoblastic leukemia Immunologic diseases. Allergy RC581-607
spellingShingle	immunity non-lymphoblastic leukemia lymphoblastic leukemia Immunologic diseases. Allergy RC581-607 O. V. Smirnova A. A. Savchenko V. T. Manchuk STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
description	Abstract. We examined immunological state in 100 patients with acute non-lymphoblastic leukemia (ANLL, M4), and in 73 cases of acute lymphoblastic leukemia (ALL, common variant). The most expressed disturbances of immune status in ANLL patients were revealed during relapses, and in patients with ALL they were detected in the state of clinical remission. In cases of ANLL, T cell immunodeficiency did develop in crisis and remission, whereas combined T- and B-cell immunodeficiency occurs during relapse of ANLL. T cell immunodeficiency was found to develop at all stages of ALL. These changes and differences may characterize specific immunopathogenetic aspects of development and progression of ANLL and acute ALL.
format	article
author	O. V. Smirnova A. A. Savchenko V. T. Manchuk
author_facet	O. V. Smirnova A. A. Savchenko V. T. Manchuk
author_sort	O. V. Smirnova
title	STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_short	STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_full	STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_fullStr	STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_full_unstemmed	STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA
title_sort	stage-dependent immunopathogenetic features of acute nonlymphoblastic and acute lymphoblastic leukemia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c4655c09d0ca4de6975decea35ebf714
work_keys_str_mv	AT ovsmirnova stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia AT aasavchenko stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia AT vtmanchuk stagedependentimmunopathogeneticfeaturesofacutenonlymphoblasticandacutelymphoblasticleukemia
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STAGE-DEPENDENT IMMUNOPATHOGENETIC FEATURES OF ACUTE NONLYMPHOBLASTIC AND ACUTE LYMPHOBLASTIC LEUKEMIA

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