mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach

ABSTRACT Rory de Vries works in the field of viral pathogenesis and focuses on interactions between respiratory viruses (or corresponding vaccines) and the host immune system. In this mSphere of Influence article, he reflects on how the articles “Predominant infection of CD150+ lymphocytes and dendr...

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Autor principal:	Rory D. de Vries
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	measles virus pathogenesis virology virus-host interactions Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c4671997bfee4cb99604b824c593404d
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spelling	oai:doaj.org-article:c4671997bfee4cb99604b824c593404d2021-11-15T15:29:17ZmSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach10.1128/mSphere.00105-202379-5042https://doaj.org/article/c4671997bfee4cb99604b824c593404d2020-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00105-20https://doaj.org/toc/2379-5042ABSTRACT Rory de Vries works in the field of viral pathogenesis and focuses on interactions between respiratory viruses (or corresponding vaccines) and the host immune system. In this mSphere of Influence article, he reflects on how the articles “Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques” by R. L. de Swart et al. (R. L. de Swart, M. Ludlow, L. de Witte, Y. Yanagi, et al., PLoS Pathog 3:e178, 2007, https://doi.org/10.1371/journal.ppat.0030178) and “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality” by M. J. Mina et al. (M. J. Mina, C. J. Metcalf, R. L. de Swart, A. D. M. E. Osterhaus, and B. T. Grenfell, Science 348:694–699, 2015, https://doi.org/10.1126/science.aaa3662) made an impact on him. These articles studied interactions between measles virus and the host and influenced him by making two important points. (i) It is crucial to use nonadapted (recombinant) viruses in disease-relevant model systems when studying virus-host interactions. (ii) Studying viral pathogenesis requires a combination of in vitro, ex vivo, and in vivo studies, and a group of researchers with multiple expertises. He learned that only when all these aspects are combined, can one truly answer the question: “How does a virus cause disease?”Rory D. de VriesAmerican Society for Microbiologyarticlemeasles viruspathogenesisvirologyvirus-host interactionsMicrobiologyQR1-502ENmSphere, Vol 5, Iss 2 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	measles virus pathogenesis virology virus-host interactions Microbiology QR1-502
spellingShingle	measles virus pathogenesis virology virus-host interactions Microbiology QR1-502 Rory D. de Vries mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
description	ABSTRACT Rory de Vries works in the field of viral pathogenesis and focuses on interactions between respiratory viruses (or corresponding vaccines) and the host immune system. In this mSphere of Influence article, he reflects on how the articles “Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques” by R. L. de Swart et al. (R. L. de Swart, M. Ludlow, L. de Witte, Y. Yanagi, et al., PLoS Pathog 3:e178, 2007, https://doi.org/10.1371/journal.ppat.0030178) and “Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality” by M. J. Mina et al. (M. J. Mina, C. J. Metcalf, R. L. de Swart, A. D. M. E. Osterhaus, and B. T. Grenfell, Science 348:694–699, 2015, https://doi.org/10.1126/science.aaa3662) made an impact on him. These articles studied interactions between measles virus and the host and influenced him by making two important points. (i) It is crucial to use nonadapted (recombinant) viruses in disease-relevant model systems when studying virus-host interactions. (ii) Studying viral pathogenesis requires a combination of in vitro, ex vivo, and in vivo studies, and a group of researchers with multiple expertises. He learned that only when all these aspects are combined, can one truly answer the question: “How does a virus cause disease?”
format	article
author	Rory D. de Vries
author_facet	Rory D. de Vries
author_sort	Rory D. de Vries
title	mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
title_short	mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
title_full	mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
title_fullStr	mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
title_full_unstemmed	mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach
title_sort	msphere of influence: understanding virus-host interactions requires a multifaceted approach
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/c4671997bfee4cb99604b824c593404d
work_keys_str_mv	AT roryddevries msphereofinfluenceunderstandingvirushostinteractionsrequiresamultifacetedapproach
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mSphere of Influence: Understanding Virus-Host Interactions Requires a Multifaceted Approach

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