Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity

Abstract Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-re...

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Autores principales:	Mahsa Mahmoudinezhad, Mahdieh Abbasalizad Farhangi, Houman Kahroba, Parvin Dehghan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c46a2dc238834a32ac8ed6ff18a905d5
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spelling	oai:doaj.org-article:c46a2dc238834a32ac8ed6ff18a905d52021-12-02T17:13:17ZPersonalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity10.1038/s41598-021-99077-32045-2322https://doaj.org/article/c46a2dc238834a32ac8ed6ff18a905d52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99077-3https://doaj.org/toc/2045-2322Abstract Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. The present cross-sectional study conducted among 347 obese individuals. A validated semi-quantitative 147-item food frequency questionnaire (FFQ) was used to estimate dietary intakes and American multiethnic database was used to calculate AGEs content of food items which were not available in Iranian Food Composition Table (FCT). FADS2 gene variants were determined according to Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Analysis of covariance (ANCOVA) was used to evaluate the modifier effect of FADS2 gene-dietary AGEs on biochemical values. Based on our findings, no significant differences was reported in term of biochemical variables between AGEs tertiles. In contrast, percent of macronutrients (carbohydrate, protein and fat) of total calorie intake, amount of daily intake of fiber and meat groups showed a significant differences among AGEs tertiles. Furthermore, statistical assays clarified the modifier effects of FADS2 gene-AGEs on weight (Pinteraction = 0.04), fat mass (Pinteraction = 0.03), waist circumference (Pinteraction = 0.008) and cholesterol (Pinteraction = 0.04) level. Accordingly, higher consumption of protein or fat based foods constitute high amount of AGEs and heterozygote genotype for FADS2 tended to show lower level of AGEs content. These findings address further investigation to develop new approaches for nutritional interventions.Mahsa MahmoudinezhadMahdieh Abbasalizad FarhangiHouman KahrobaParvin DehghanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mahsa Mahmoudinezhad Mahdieh Abbasalizad Farhangi Houman Kahroba Parvin Dehghan Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
description	Abstract Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS2) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. The present cross-sectional study conducted among 347 obese individuals. A validated semi-quantitative 147-item food frequency questionnaire (FFQ) was used to estimate dietary intakes and American multiethnic database was used to calculate AGEs content of food items which were not available in Iranian Food Composition Table (FCT). FADS2 gene variants were determined according to Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Analysis of covariance (ANCOVA) was used to evaluate the modifier effect of FADS2 gene-dietary AGEs on biochemical values. Based on our findings, no significant differences was reported in term of biochemical variables between AGEs tertiles. In contrast, percent of macronutrients (carbohydrate, protein and fat) of total calorie intake, amount of daily intake of fiber and meat groups showed a significant differences among AGEs tertiles. Furthermore, statistical assays clarified the modifier effects of FADS2 gene-AGEs on weight (Pinteraction = 0.04), fat mass (Pinteraction = 0.03), waist circumference (Pinteraction = 0.008) and cholesterol (Pinteraction = 0.04) level. Accordingly, higher consumption of protein or fat based foods constitute high amount of AGEs and heterozygote genotype for FADS2 tended to show lower level of AGEs content. These findings address further investigation to develop new approaches for nutritional interventions.
format	article
author	Mahsa Mahmoudinezhad Mahdieh Abbasalizad Farhangi Houman Kahroba Parvin Dehghan
author_facet	Mahsa Mahmoudinezhad Mahdieh Abbasalizad Farhangi Houman Kahroba Parvin Dehghan
author_sort	Mahsa Mahmoudinezhad
title	Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
title_short	Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
title_full	Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
title_fullStr	Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
title_full_unstemmed	Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity
title_sort	personalized diet study of dietary advanced glycation end products (ages) and fatty acid desaturase 2 (fads2) genotypes in obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c46a2dc238834a32ac8ed6ff18a905d5
work_keys_str_mv	AT mahsamahmoudinezhad personalizeddietstudyofdietaryadvancedglycationendproductsagesandfattyaciddesaturase2fads2genotypesinobesity AT mahdiehabbasalizadfarhangi personalizeddietstudyofdietaryadvancedglycationendproductsagesandfattyaciddesaturase2fads2genotypesinobesity AT houmankahroba personalizeddietstudyofdietaryadvancedglycationendproductsagesandfattyaciddesaturase2fads2genotypesinobesity AT parvindehghan personalizeddietstudyofdietaryadvancedglycationendproductsagesandfattyaciddesaturase2fads2genotypesinobesity
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Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS2) genotypes in obesity

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