Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China

Objective This study investigated the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and the severity and prognosis of renal injury in lupus nephritis (LN). Methods Serum sCD163 levels in 121 Eastern Chinese patients with LN who underwent renal biopsy were determ...

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Autores principales:	Guangxia Yang, Naifeng Guo, Jun Yin, Jianhua Wu
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c46b79397db743f6babfc539584b5f9f
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spelling	oai:doaj.org-article:c46b79397db743f6babfc539584b5f9f2021-11-11T01:33:27ZElevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China1473-230010.1177/03000605211049963https://doaj.org/article/c46b79397db743f6babfc539584b5f9f2021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211049963https://doaj.org/toc/1473-2300Objective This study investigated the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and the severity and prognosis of renal injury in lupus nephritis (LN). Methods Serum sCD163 levels in 121 Eastern Chinese patients with LN who underwent renal biopsy were determined by enzyme-linked immunosorbent assays. Clinical data were collected, and the glomerular filtration rate and disease activity score of lupus were calculated. Pathological classification was performed, and renal pathological scores were assessed by the activity index (AI) and chronic index (CI). Kaplan–Meier survival curves were drawn to evaluate prognosis. Results The pathological classification, AI and CI scores in the high sCD163 group were increased. The sCD163 levels were positively correlated with serum creatinine, blood urea nitrogen, AI scores and CI scores and negatively correlated with the estimated glomerular filtration rate. Kaplan–Meier survival analysis showed that the incidence of renal endpoint events was increased in the high sCD163 group compared with the normal sCD163 group. Conclusion The serum sCD163 level correlates with the severity of LN and is an important indicator of poor renal prognosis in patients with LN.Guangxia YangNaifeng GuoJun YinJianhua WuSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Guangxia Yang Naifeng Guo Jun Yin Jianhua Wu Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
description	Objective This study investigated the association between soluble scavenger receptor differentiation antigen 163 (sCD163) and the severity and prognosis of renal injury in lupus nephritis (LN). Methods Serum sCD163 levels in 121 Eastern Chinese patients with LN who underwent renal biopsy were determined by enzyme-linked immunosorbent assays. Clinical data were collected, and the glomerular filtration rate and disease activity score of lupus were calculated. Pathological classification was performed, and renal pathological scores were assessed by the activity index (AI) and chronic index (CI). Kaplan–Meier survival curves were drawn to evaluate prognosis. Results The pathological classification, AI and CI scores in the high sCD163 group were increased. The sCD163 levels were positively correlated with serum creatinine, blood urea nitrogen, AI scores and CI scores and negatively correlated with the estimated glomerular filtration rate. Kaplan–Meier survival analysis showed that the incidence of renal endpoint events was increased in the high sCD163 group compared with the normal sCD163 group. Conclusion The serum sCD163 level correlates with the severity of LN and is an important indicator of poor renal prognosis in patients with LN.
format	article
author	Guangxia Yang Naifeng Guo Jun Yin Jianhua Wu
author_facet	Guangxia Yang Naifeng Guo Jun Yin Jianhua Wu
author_sort	Guangxia Yang
title	Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
title_short	Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
title_full	Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
title_fullStr	Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
title_full_unstemmed	Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China
title_sort	elevated soluble cd163 predicts renal function deterioration in lupus nephritis: a cohort study in eastern china
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/c46b79397db743f6babfc539584b5f9f
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_version_	1718439625556492288

Elevated soluble CD163 predicts renal function deterioration in lupus nephritis: a cohort study in Eastern China

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