Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical properties.

Point mutations in the transmembrane region of the clic1 ion channel selectively modify its biophysical properties.

Chloride intracellular Channel 1 (CLIC1) is a metamorphic protein that changes from a soluble cytoplasmic protein into a transmembrane protein. Once inserted into membranes, CLIC1 multimerises and is able to form chloride selective ion channels. Whilst CLIC1 behaves as an ion channel both in cells a...

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Autores principales: Stefania Averaimo, Rosella Abeti, Nicoletta Savalli, Louise J Brown, Paul M G Curmi, Samuel N Breit, Michele Mazzanti
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/c46ef3aaca374bb39244bdde8d74f8bd
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