Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)

Heidemarie Abrahamian,1 Peter Hofmann,2 Johann Kinzl,4 Hermann Toplak31Department of Internal Medicine, Otto Wagner Hospital, Vienna, Austria; 2Department of Psychiatry, 3Department of Internal Medicine, University Hospital, Graz, Austria; 4Department of Psychosomatic Medicine, University Hospital,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Abrahamian H, Hofmann P, Kinzl J, Toplak H
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://doaj.org/article/c46f0237a4764607b178c3bb305b2d83
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:c46f0237a4764607b178c3bb305b2d83
record_format dspace
spelling oai:doaj.org-article:c46f0237a4764607b178c3bb305b2d832021-12-02T07:42:15Z Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)1176-63281178-2021https://doaj.org/article/c46f0237a4764607b178c3bb305b2d832012-08-01T00:00:00Zhttp://www.dovepress.com/nbspdiabetes-mellitus-and-comorbid-depression-improvement-of-both-dise-a10687https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Heidemarie Abrahamian,1 Peter Hofmann,2 Johann Kinzl,4 Hermann Toplak31Department of Internal Medicine, Otto Wagner Hospital, Vienna, Austria; 2Department of Psychiatry, 3Department of Internal Medicine, University Hospital, Graz, Austria; 4Department of Psychosomatic Medicine, University Hospital, Innsbruck, AustriaAbstract: Co-morbid depression is common in patients with type 2 diabetes mellitus and is associated with greater mortality risk and a higher incidence of diabetic complications and decreased quality of life. In an earlier pilot study, we found that treatment with the serotonin norepinephrine reuptake inhibitor antidepressant, milnacipran, significantly improved metabolic parameters in diabetic patients with comorbid depression who had an antidepressant response. We sought to replicate these results in a larger cohort (n = 135). Patients received milnacipran and metformin for 6 months and metabolic parameters and depressive symptoms were measured at baseline and after 3 and 6 months. At the end of the study, 72.6% of patients had an antidepressant response (≥50% reduction of baseline Beck Depression Inventory score). Overall, there was significant improvement in the metabolic and anthropometric parameters measured. The number of patients with glycated hemoglobin > 8% (>63.9 mmol/mol), an indicator of poor metabolic control requiring intensive therapeutic intervention, decreased from 31.9% at baseline to 11.9% during the study. As found in the pilot study, levels of total cholesterol and triglycerides were only significantly decreased in antidepressant responders. Body weight was significantly reduced in both responders and non-responders but the effect size was significantly greater in the responder group. In contrast to the pilot study, fasting blood glucose and glycated hemoglobin were significantly decreased to a similar extent in both antidepressant-responders and nonresponders. The present study thus replicates some of the original findings. The main difference between the present and the pilot study is that in the larger cohort significant reductions in fasting blood glucose and glycated hemoglobin were found in all patients irrespective of whether or not they responded to antidepressant treatment. The present data underline the importance of diagnosis and treatment of comorbid depression in patients with type 2 diabetes mellitus with milnacipran.Keywords: depression, diabetes, milnacipran, metabolic control, metforminAbrahamian HHofmann PKinzl JToplak HDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 355-360 (2012)
institution DOAJ
collection DOAJ
language EN
topic Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Abrahamian H
Hofmann P
Kinzl J
Toplak H
 Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
description Heidemarie Abrahamian,1 Peter Hofmann,2 Johann Kinzl,4 Hermann Toplak31Department of Internal Medicine, Otto Wagner Hospital, Vienna, Austria; 2Department of Psychiatry, 3Department of Internal Medicine, University Hospital, Graz, Austria; 4Department of Psychosomatic Medicine, University Hospital, Innsbruck, AustriaAbstract: Co-morbid depression is common in patients with type 2 diabetes mellitus and is associated with greater mortality risk and a higher incidence of diabetic complications and decreased quality of life. In an earlier pilot study, we found that treatment with the serotonin norepinephrine reuptake inhibitor antidepressant, milnacipran, significantly improved metabolic parameters in diabetic patients with comorbid depression who had an antidepressant response. We sought to replicate these results in a larger cohort (n = 135). Patients received milnacipran and metformin for 6 months and metabolic parameters and depressive symptoms were measured at baseline and after 3 and 6 months. At the end of the study, 72.6% of patients had an antidepressant response (≥50% reduction of baseline Beck Depression Inventory score). Overall, there was significant improvement in the metabolic and anthropometric parameters measured. The number of patients with glycated hemoglobin > 8% (>63.9 mmol/mol), an indicator of poor metabolic control requiring intensive therapeutic intervention, decreased from 31.9% at baseline to 11.9% during the study. As found in the pilot study, levels of total cholesterol and triglycerides were only significantly decreased in antidepressant responders. Body weight was significantly reduced in both responders and non-responders but the effect size was significantly greater in the responder group. In contrast to the pilot study, fasting blood glucose and glycated hemoglobin were significantly decreased to a similar extent in both antidepressant-responders and nonresponders. The present study thus replicates some of the original findings. The main difference between the present and the pilot study is that in the larger cohort significant reductions in fasting blood glucose and glycated hemoglobin were found in all patients irrespective of whether or not they responded to antidepressant treatment. The present data underline the importance of diagnosis and treatment of comorbid depression in patients with type 2 diabetes mellitus with milnacipran.Keywords: depression, diabetes, milnacipran, metabolic control, metformin
format article
author Abrahamian H
Hofmann P
Kinzl J
Toplak H
author_facet Abrahamian H
Hofmann P
Kinzl J
Toplak H
author_sort Abrahamian H
title  Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
title_short  Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
title_full  Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
title_fullStr  Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
title_full_unstemmed  Diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. A replication study (results of the Austrian Major Depression Diabetes Mellitus study group)
title_sort  diabetes mellitus and comorbid depression: improvement of both diseases with milnacipran. a replication study (results of the austrian major depression diabetes mellitus study group)
publisher Dove Medical Press
publishDate 2012
url https://doaj.org/article/c46f0237a4764607b178c3bb305b2d83
work_keys_str_mv AT abrahamianh ampnbspdiabetesmellitusandcomorbiddepressionimprovementofbothdiseaseswithmilnacipranareplicationstudyresultsoftheaustrianmajordepressiondiabetesmellitusstudygroup
AT hofmannp ampnbspdiabetesmellitusandcomorbiddepressionimprovementofbothdiseaseswithmilnacipranareplicationstudyresultsoftheaustrianmajordepressiondiabetesmellitusstudygroup
AT kinzlj ampnbspdiabetesmellitusandcomorbiddepressionimprovementofbothdiseaseswithmilnacipranareplicationstudyresultsoftheaustrianmajordepressiondiabetesmellitusstudygroup
AT toplakh ampnbspdiabetesmellitusandcomorbiddepressionimprovementofbothdiseaseswithmilnacipranareplicationstudyresultsoftheaustrianmajordepressiondiabetesmellitusstudygroup
_version_ 1718399246946795520