Pathological features and pathological diagnosis of drug-induced liver injury

Based on liver histology, drug-induced liver injury (DILI) is classified as various pathological types of inflammatory necrosis, cholestasis, fatty degeneration and fatty liver disease, vascular injury, and minimal lesion. Histopathological examination is required for further differential diagnosis...

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Autor principal:	YANG Yongfeng
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Clinical Hepatology 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/c4732eef13924872a9bbb80917388927
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spelling	oai:doaj.org-article:c4732eef13924872a9bbb809173889272021-11-17T10:37:40ZPathological features and pathological diagnosis of drug-induced liver injury1001-5256https://doaj.org/article/c4732eef13924872a9bbb809173889272021-11-01T00:00:00Zhttp://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.11.005https://doaj.org/toc/1001-5256Based on liver histology, drug-induced liver injury (DILI) is classified as various pathological types of inflammatory necrosis, cholestasis, fatty degeneration and fatty liver disease, vascular injury, and minimal lesion. Histopathological examination is required for further differential diagnosis in suspected cases of DILI, liver injury that cannot be explained by DILI monogenesis, DILI cases with a history of exposure to various drugs in which the specific drug causing liver injury cannot be determined, DILI cases with unsatisfactory treatment outcome, and chronic DILI, and histopathological examination can also be used to evaluate the severity and prognosis of DILI. Since liver lesions are unevenly distributed in DILI, adequate tissue samples are needed to reduce sampling error. The histopathological manifestation of liver injury diseases has the features of “one cause with multiple results and one result with multiple causes”, and a combination of pathological examination and clinical symptoms can help to make a confirmed diagnosis, suggesting that clinicopathological discussion is of great importance in the histological diagnosis of DILI.YANG YongfengEditorial Department of Journal of Clinical HepatologyarticleDiseases of the digestive system. GastroenterologyRC799-869ZHLinchuang Gandanbing Zazhi, Vol 37, Iss 11, Pp 2530-2533 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 YANG Yongfeng Pathological features and pathological diagnosis of drug-induced liver injury
description	Based on liver histology, drug-induced liver injury (DILI) is classified as various pathological types of inflammatory necrosis, cholestasis, fatty degeneration and fatty liver disease, vascular injury, and minimal lesion. Histopathological examination is required for further differential diagnosis in suspected cases of DILI, liver injury that cannot be explained by DILI monogenesis, DILI cases with a history of exposure to various drugs in which the specific drug causing liver injury cannot be determined, DILI cases with unsatisfactory treatment outcome, and chronic DILI, and histopathological examination can also be used to evaluate the severity and prognosis of DILI. Since liver lesions are unevenly distributed in DILI, adequate tissue samples are needed to reduce sampling error. The histopathological manifestation of liver injury diseases has the features of “one cause with multiple results and one result with multiple causes”, and a combination of pathological examination and clinical symptoms can help to make a confirmed diagnosis, suggesting that clinicopathological discussion is of great importance in the histological diagnosis of DILI.
format	article
author	YANG Yongfeng
author_facet	YANG Yongfeng
author_sort	YANG Yongfeng
title	Pathological features and pathological diagnosis of drug-induced liver injury
title_short	Pathological features and pathological diagnosis of drug-induced liver injury
title_full	Pathological features and pathological diagnosis of drug-induced liver injury
title_fullStr	Pathological features and pathological diagnosis of drug-induced liver injury
title_full_unstemmed	Pathological features and pathological diagnosis of drug-induced liver injury
title_sort	pathological features and pathological diagnosis of drug-induced liver injury
publisher	Editorial Department of Journal of Clinical Hepatology
publishDate	2021
url	https://doaj.org/article/c4732eef13924872a9bbb80917388927
work_keys_str_mv	AT yangyongfeng pathologicalfeaturesandpathologicaldiagnosisofdruginducedliverinjury
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Pathological features and pathological diagnosis of drug-induced liver injury

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