Reagent-controlled regiodivergent ring expansions of steroids

Late-stage diversification of natural products is an important starting point for drug discovery. Here, the authors use chiral reagents to perform the regiocontrolled ring expansion of steroid precursors and achieve more than 100 isomerically pure analogs with spatial and functional diversity.

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Bibliographic Details
Main Authors:	Manwika Charaschanya, Jeffrey Aubé
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/c474749e5c3742fcb1e3a9c7bde664bc
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spelling	oai:doaj.org-article:c474749e5c3742fcb1e3a9c7bde664bc2021-12-02T16:56:38ZReagent-controlled regiodivergent ring expansions of steroids10.1038/s41467-018-03248-22041-1723https://doaj.org/article/c474749e5c3742fcb1e3a9c7bde664bc2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03248-2https://doaj.org/toc/2041-1723Late-stage diversification of natural products is an important starting point for drug discovery. Here, the authors use chiral reagents to perform the regiocontrolled ring expansion of steroid precursors and achieve more than 100 isomerically pure analogs with spatial and functional diversity.Manwika CharaschanyaJeffrey AubéNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manwika Charaschanya Jeffrey Aubé Reagent-controlled regiodivergent ring expansions of steroids
description	Late-stage diversification of natural products is an important starting point for drug discovery. Here, the authors use chiral reagents to perform the regiocontrolled ring expansion of steroid precursors and achieve more than 100 isomerically pure analogs with spatial and functional diversity.
format	article
author	Manwika Charaschanya Jeffrey Aubé
author_facet	Manwika Charaschanya Jeffrey Aubé
author_sort	Manwika Charaschanya
title	Reagent-controlled regiodivergent ring expansions of steroids
title_short	Reagent-controlled regiodivergent ring expansions of steroids
title_full	Reagent-controlled regiodivergent ring expansions of steroids
title_fullStr	Reagent-controlled regiodivergent ring expansions of steroids
title_full_unstemmed	Reagent-controlled regiodivergent ring expansions of steroids
title_sort	reagent-controlled regiodivergent ring expansions of steroids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c474749e5c3742fcb1e3a9c7bde664bc
work_keys_str_mv	AT manwikacharaschanya reagentcontrolledregiodivergentringexpansionsofsteroids AT jeffreyaube reagentcontrolledregiodivergentringexpansionsofsteroids
_version_	1718382768569712640

Reagent-controlled regiodivergent ring expansions of steroids

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