Reagent-controlled regiodivergent ring expansions of steroids

Late-stage diversification of natural products is an important starting point for drug discovery. Here, the authors use chiral reagents to perform the regiocontrolled ring expansion of steroid precursors and achieve more than 100 isomerically pure analogs with spatial and functional diversity.

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Auteurs principaux: Manwika Charaschanya, Jeffrey Aubé
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/c474749e5c3742fcb1e3a9c7bde664bc
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