Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability

Xiangli Xu,1 Yang Hua,2 Beibei Liu,2 Fubo Zhou,2 Lili Wang,2 Weihong Hou2 1Department of Ultrasound, the Second Hospital of Harbin, Harbin, People’s Republic of China; 2Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorresponde...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xu X, Hua Y, Liu B, Zhou F, Wang L, Hou W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	carotid artery atherosclerotic plaque intraplaque calcification vulnerable plaque Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c476df1e24914f7695c8f4e987ee8337
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c476df1e24914f7695c8f4e987ee8337
record_format	dspace
spelling	oai:doaj.org-article:c476df1e24914f7695c8f4e987ee83372021-12-02T14:34:18ZCorrelation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability1178-203Xhttps://doaj.org/article/c476df1e24914f7695c8f4e987ee83372021-07-01T00:00:00Zhttps://www.dovepress.com/correlation-between-calcification-characteristics-of-carotid-atheroscl-peer-reviewed-fulltext-article-TCRMhttps://doaj.org/toc/1178-203XXiangli Xu,1 Yang Hua,2 Beibei Liu,2 Fubo Zhou,2 Lili Wang,2 Weihong Hou2 1Department of Ultrasound, the Second Hospital of Harbin, Harbin, People’s Republic of China; 2Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yang HuaDepartment of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Road, Beijing, 100053, People’s Republic of ChinaTel +86-10-83198923Fax +86-10-83198967Email dryanghua99@163.comPurpose: To investigate the relationship between calcification characteristics of carotid atherosclerotic plaque and lipid rich necrotic core (LRNC) and intraplaque hemorrhage (IPH).Methods: Patients with severe carotid stenosis undergoing carotid endarterectomy (CEA) were selected. Ultrasound and CT angiography (CTA) were performed to evaluate the calcification characteristics of the plaque before the surgery.Results: A total of 142 patients were included and 142 pathological specimens of postoperative plaque were obtained accordingly. There were 78 plaques (54.9%) with LRNC and 41 (28.9%) with IPH. The plaque with LRNC had higher calcification rate (93.6%) compared with the plaque with IPH (87.8%). LRNC was often found in multiple calcification (P = 0.003) and mixed type calcification (P = 0.001). Multiple calcification was more likely to combine with IPH (P = 0.008), while simple basal calcification was not likely to combine IPH (P = 0.002). Smaller granular calcification was more likely to be associated with IPH (P < 0.05). In multivariate regression analysis of IPH and calcification characteristics, simple basal calcification was still a protective factor for IPH (OR, 0.25; 95% CI, 0.09– 0.66; P = 0.005), while multiple calcification was closely related to the occurrence of IPH (OR, 3.58; 95% CI, 1.49– 8.61; P = 0.004).Conclusion: Calcification characteristics of carotid atherosclerotic plaques are closely related to the vulnerability of plaques, especially multiple calcification and mixed type calcification.Keywords: carotid artery, atherosclerotic plaque, intraplaque calcification, vulnerable plaqueXu XHua YLiu BZhou FWang LHou WDove Medical Pressarticlecarotid arteryatherosclerotic plaqueintraplaque calcificationvulnerable plaqueTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 679-690 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carotid artery atherosclerotic plaque intraplaque calcification vulnerable plaque Therapeutics. Pharmacology RM1-950
spellingShingle	carotid artery atherosclerotic plaque intraplaque calcification vulnerable plaque Therapeutics. Pharmacology RM1-950 Xu X Hua Y Liu B Zhou F Wang L Hou W Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
description	Xiangli Xu,1 Yang Hua,2 Beibei Liu,2 Fubo Zhou,2 Lili Wang,2 Weihong Hou2 1Department of Ultrasound, the Second Hospital of Harbin, Harbin, People’s Republic of China; 2Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Yang HuaDepartment of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Road, Beijing, 100053, People’s Republic of ChinaTel +86-10-83198923Fax +86-10-83198967Email dryanghua99@163.comPurpose: To investigate the relationship between calcification characteristics of carotid atherosclerotic plaque and lipid rich necrotic core (LRNC) and intraplaque hemorrhage (IPH).Methods: Patients with severe carotid stenosis undergoing carotid endarterectomy (CEA) were selected. Ultrasound and CT angiography (CTA) were performed to evaluate the calcification characteristics of the plaque before the surgery.Results: A total of 142 patients were included and 142 pathological specimens of postoperative plaque were obtained accordingly. There were 78 plaques (54.9%) with LRNC and 41 (28.9%) with IPH. The plaque with LRNC had higher calcification rate (93.6%) compared with the plaque with IPH (87.8%). LRNC was often found in multiple calcification (P = 0.003) and mixed type calcification (P = 0.001). Multiple calcification was more likely to combine with IPH (P = 0.008), while simple basal calcification was not likely to combine IPH (P = 0.002). Smaller granular calcification was more likely to be associated with IPH (P < 0.05). In multivariate regression analysis of IPH and calcification characteristics, simple basal calcification was still a protective factor for IPH (OR, 0.25; 95% CI, 0.09– 0.66; P = 0.005), while multiple calcification was closely related to the occurrence of IPH (OR, 3.58; 95% CI, 1.49– 8.61; P = 0.004).Conclusion: Calcification characteristics of carotid atherosclerotic plaques are closely related to the vulnerability of plaques, especially multiple calcification and mixed type calcification.Keywords: carotid artery, atherosclerotic plaque, intraplaque calcification, vulnerable plaque
format	article
author	Xu X Hua Y Liu B Zhou F Wang L Hou W
author_facet	Xu X Hua Y Liu B Zhou F Wang L Hou W
author_sort	Xu X
title	Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
title_short	Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
title_full	Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
title_fullStr	Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
title_full_unstemmed	Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability
title_sort	correlation between calcification characteristics of carotid atherosclerotic plaque and plaque vulnerability
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/c476df1e24914f7695c8f4e987ee8337
work_keys_str_mv	AT xux correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability AT huay correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability AT liub correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability AT zhouf correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability AT wangl correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability AT houw correlationbetweencalcificationcharacteristicsofcarotidatheroscleroticplaqueandplaquevulnerability
_version_	1718391156275937280

Correlation Between Calcification Characteristics of Carotid Atherosclerotic Plaque and Plaque Vulnerability

Ejemplares similares