Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis

There is evidence that probiotics have a broad antitumor effect in colorectal cancer (CRC). However, the mechanism remains obscure. Here, we investigated the effect of Bornlisy (BO)-cocktails of three probiotics on colitis-associated colon cancer (CAC) and the underlying mechanism. The treatment of...

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Autores principales:	Xia Lu, Shuping Qiao, Chen Peng, Wenyue Yan, Zhen Xu, Junxing Qu, Yayi Hou, Shuli Zhao, Ping Chen, Tingting Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	colitis-associated colon cancer probiotic metabolism reprogramming glycolysis GPR43 Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c478a77ea373466691231267bc01fadd
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id	oai:doaj.org-article:c478a77ea373466691231267bc01fadd
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spelling	oai:doaj.org-article:c478a77ea373466691231267bc01fadd2021-11-12T05:31:58ZBornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis2296-861X10.3389/fnut.2021.706382https://doaj.org/article/c478a77ea373466691231267bc01fadd2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.706382/fullhttps://doaj.org/toc/2296-861XThere is evidence that probiotics have a broad antitumor effect in colorectal cancer (CRC). However, the mechanism remains obscure. Here, we investigated the effect of Bornlisy (BO)-cocktails of three probiotics on colitis-associated colon cancer (CAC) and the underlying mechanism. The treatment of CAC mice with BO resulted in decreased tumor loads as compared with their counterparts. BO also inhibited the proliferation and metastasis of CRC cells in vitro. Furthermore, BO inhibited cell proliferation through downregulating glycolysis. Activating glycolysis reversed the protective role of BO in the CAC mice. Mechanically, BO administration promoted the activation of GPR43, followed by its downstream PLC-PKC-ERK pathway, which led to decreased glucose metabolism. These results suggest that BO may provide an intervention strategy for CRC therapy, while GPR43 is a potential targeting receptor during the BO treatment.Xia LuShuping QiaoChen PengWenyue YanZhen XuJunxing QuYayi HouShuli ZhaoPing ChenTingting WangFrontiers Media S.A.articlecolitis-associated colon cancerprobioticmetabolism reprogrammingglycolysisGPR43Nutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colitis-associated colon cancer probiotic metabolism reprogramming glycolysis GPR43 Nutrition. Foods and food supply TX341-641
spellingShingle	colitis-associated colon cancer probiotic metabolism reprogramming glycolysis GPR43 Nutrition. Foods and food supply TX341-641 Xia Lu Shuping Qiao Chen Peng Wenyue Yan Zhen Xu Junxing Qu Yayi Hou Shuli Zhao Ping Chen Tingting Wang Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
description	There is evidence that probiotics have a broad antitumor effect in colorectal cancer (CRC). However, the mechanism remains obscure. Here, we investigated the effect of Bornlisy (BO)-cocktails of three probiotics on colitis-associated colon cancer (CAC) and the underlying mechanism. The treatment of CAC mice with BO resulted in decreased tumor loads as compared with their counterparts. BO also inhibited the proliferation and metastasis of CRC cells in vitro. Furthermore, BO inhibited cell proliferation through downregulating glycolysis. Activating glycolysis reversed the protective role of BO in the CAC mice. Mechanically, BO administration promoted the activation of GPR43, followed by its downstream PLC-PKC-ERK pathway, which led to decreased glucose metabolism. These results suggest that BO may provide an intervention strategy for CRC therapy, while GPR43 is a potential targeting receptor during the BO treatment.
format	article
author	Xia Lu Shuping Qiao Chen Peng Wenyue Yan Zhen Xu Junxing Qu Yayi Hou Shuli Zhao Ping Chen Tingting Wang
author_facet	Xia Lu Shuping Qiao Chen Peng Wenyue Yan Zhen Xu Junxing Qu Yayi Hou Shuli Zhao Ping Chen Tingting Wang
author_sort	Xia Lu
title	Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
title_short	Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
title_full	Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
title_fullStr	Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
title_full_unstemmed	Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis
title_sort	bornlisy attenuates colitis-associated colorectal cancer via inhibiting gpr43-mediated glycolysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c478a77ea373466691231267bc01fadd
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Bornlisy Attenuates Colitis-Associated Colorectal Cancer via Inhibiting GPR43-Mediated Glycolysis

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