Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the fo...

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Autores principales:	Samardžić Janko, Puškaš Laslo, Obradović Miljana, Lazić-Puškaš Dijana
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	gaba-a receptor inverse agonist depression forced swim test locomotor activity. Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/c47ebc8ad75a4e6da813ff26e0368f99
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spelling	oai:doaj.org-article:c47ebc8ad75a4e6da813ff26e0368f992021-11-17T21:27:52ZAntidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test1820-744810.2478/acve-2014-0006https://doaj.org/article/c47ebc8ad75a4e6da813ff26e0368f992014-03-01T00:00:00Zhttps://doi.org/10.2478/acve-2014-0006https://doaj.org/toc/1820-7448It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.Samardžić JankoPuškaš LasloObradović MiljanaLazić-Puškaš DijanaSciendoarticlegaba-a receptorinverse agonistdepressionforced swim testlocomotor activity.Veterinary medicineSF600-1100ENActa Veterinaria, Vol 64, Iss 1, Pp 52-60 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	gaba-a receptor inverse agonist depression forced swim test locomotor activity. Veterinary medicine SF600-1100
spellingShingle	gaba-a receptor inverse agonist depression forced swim test locomotor activity. Veterinary medicine SF600-1100 Samardžić Janko Puškaš Laslo Obradović Miljana Lazić-Puškaš Dijana Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
description	It has been shown in electrophysiological studies that the ligand L-655,708 possesses a binding selectivity and a moderate inverse agonist functional selectivity for α5-containing GABA-A receptors. The present study is aimed to investigate the antidepressant effects of the ligand L-655,708 in the forced swim test (FST) and its impact on locomotor activity in rats. The behavior of the animals was recorded with a digital camera, and the data were analyzed by one-way ANOVA, followed by Dunnett’s test. In FST, L-655,708 significantly decreased immobility time at a dose of 3 mg/kg after a single and repeated administration (p<0.05), exerting acute and chronic antidepressant effects. However, it did not induce significant differences in the time of struggling behavior during FST. Furthermore, L-655,708 did not show a significant effect on locomotor activity (p>0.05). These data suggest that negative modulation at GABA-A receptors containing the α5 subunit may produce antidepressant effects in rats. These effects were not confounded by locomotor influences.
format	article
author	Samardžić Janko Puškaš Laslo Obradović Miljana Lazić-Puškaš Dijana
author_facet	Samardžić Janko Puškaš Laslo Obradović Miljana Lazić-Puškaš Dijana
author_sort	Samardžić Janko
title	Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
title_short	Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
title_full	Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
title_fullStr	Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
title_full_unstemmed	Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test
title_sort	antidepressant effects of an inverse agonist selective for α5 gaba-a receptors in the rat forced swim test
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/c47ebc8ad75a4e6da813ff26e0368f99
work_keys_str_mv	AT samardzicjanko antidepressanteffectsofaninverseagonistselectivefora5gabaareceptorsintheratforcedswimtest AT puskaslaslo antidepressanteffectsofaninverseagonistselectivefora5gabaareceptorsintheratforcedswimtest AT obradovicmiljana antidepressanteffectsofaninverseagonistselectivefora5gabaareceptorsintheratforcedswimtest AT lazicpuskasdijana antidepressanteffectsofaninverseagonistselectivefora5gabaareceptorsintheratforcedswimtest
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Antidepressant effects of an inverse agonist selective for α5 GABA-A receptors in the rat forced swim test

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