ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS

In present work, some immunogenetic aspects of pulmonary tuberculosis were studied, using modern techniques from molecular genetics and immunology. It is shown that carriage of Т allele and homozygous TT genotype in +874А/Т IFNγ gene polymorphism comprise a immunogenetic factor which correlated with...

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Autores principales:	E. L. Nikulina, I. O. Naslednikova, O. I. Urazova, O. V. Voronkova, V. V. Novitsky, E. V. Nekrasov, O. V. Filiniuk, E. G. Churina, K. O. Mikheyeva, R. R. Hasanova, V. A. Serebryakova, N. A. Sukhalentseva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tuberculosis interferon-γ gene polymorphism Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c480176bea564821be370c0c102b8d1b
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spelling	oai:doaj.org-article:c480176bea564821be370c0c102b8d1b2021-11-18T08:03:38ZALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2010-3-259-264https://doaj.org/article/c480176bea564821be370c0c102b8d1b2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/104https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn present work, some immunogenetic aspects of pulmonary tuberculosis were studied, using modern techniques from molecular genetics and immunology. It is shown that carriage of Т allele and homozygous TT genotype in +874А/Т IFNγ gene polymorphism comprise a immunogenetic factor which correlated with a protective effect, regarding a susceptibility to pulmonary tuberculosis. Predisposition for tuberculosis infection is associated with A allele of this gene, as well as with АА and АТ genotypes of +874A/T IFNγ gene. Clinical evolution of pulmonary tuberculosis is accompanied by increase in IFNγ production.E. L. NikulinaI. O. NaslednikovaO. I. UrazovaO. V. VoronkovaV. V. NovitskyE. V. NekrasovO. V. FiliniukE. G. ChurinaK. O. MikheyevaR. R. HasanovaV. A. SerebryakovaN. A. SukhalentsevaSPb RAACIarticletuberculosisinterferon-γgene polymorphismImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 3, Pp 259-264 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis interferon-γ gene polymorphism Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis interferon-γ gene polymorphism Immunologic diseases. Allergy RC581-607 E. L. Nikulina I. O. Naslednikova O. I. Urazova O. V. Voronkova V. V. Novitsky E. V. Nekrasov O. V. Filiniuk E. G. Churina K. O. Mikheyeva R. R. Hasanova V. A. Serebryakova N. A. Sukhalentseva ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
description	In present work, some immunogenetic aspects of pulmonary tuberculosis were studied, using modern techniques from molecular genetics and immunology. It is shown that carriage of Т allele and homozygous TT genotype in +874А/Т IFNγ gene polymorphism comprise a immunogenetic factor which correlated with a protective effect, regarding a susceptibility to pulmonary tuberculosis. Predisposition for tuberculosis infection is associated with A allele of this gene, as well as with АА and АТ genotypes of +874A/T IFNγ gene. Clinical evolution of pulmonary tuberculosis is accompanied by increase in IFNγ production.
format	article
author	E. L. Nikulina I. O. Naslednikova O. I. Urazova O. V. Voronkova V. V. Novitsky E. V. Nekrasov O. V. Filiniuk E. G. Churina K. O. Mikheyeva R. R. Hasanova V. A. Serebryakova N. A. Sukhalentseva
author_facet	E. L. Nikulina I. O. Naslednikova O. I. Urazova O. V. Voronkova V. V. Novitsky E. V. Nekrasov O. V. Filiniuk E. G. Churina K. O. Mikheyeva R. R. Hasanova V. A. Serebryakova N. A. Sukhalentseva
author_sort	E. L. Nikulina
title	ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_short	ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full	ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_fullStr	ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_full_unstemmed	ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS
title_sort	allelic polymorphism of ifnγ gene in patients with pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/c480176bea564821be370c0c102b8d1b
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ALLELIC POLYMORPHISM OF IFNγ GENE IN PATIENTS WITH PULMONARY TUBERCULOSIS

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