Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension

Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs) results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous afflictions is crucial for glaucoma treatment. In this study, we aimed to investigate the beneficial effects of statins...

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Autores principales:	Mi-Lyang Kim, Kyung Rim Sung, Junki Kwon, Go Woon Choi, Jin A Shin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	retinal ganglion cell statin glaucoma neuroprotection ocular hypertension Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c4801c941ff54baea351cff86f4deb7e
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spelling	oai:doaj.org-article:c4801c941ff54baea351cff86f4deb7e2021-11-25T17:57:20ZNeuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension10.3390/ijms2222125001422-00671661-6596https://doaj.org/article/c4801c941ff54baea351cff86f4deb7e2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12500https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs) results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous afflictions is crucial for glaucoma treatment. In this study, we aimed to investigate the beneficial effects of statins in the protection of RGCs using a rat model. Glaucomatous injury was induced in rats by chronic ocular hypertension (OHT) achieved after performing a circumlimbal suture. The rats were given either statins such as simvastatin and atorvastatin or a solvent weekly for 6 weeks. Retina sections underwent hematoxylin and eosin, Brn3a, or cleaved casepase-3 staining to evaluate RGC survival. In addition, modulation of glial activation was assessed. While the retinas without statin treatment exhibited increased RGC death due to chronic OHT, statins promoted the survival of RGCs and reduced apoptosis. Statins also suppressed chronic OHT-mediated glial activation in the retina. Our results demonstrate that statins exert neuroprotective effects in rat retinas exposed to chronic OHT, which may support the prospect of statins being a glaucoma treatment.Mi-Lyang KimKyung Rim SungJunki KwonGo Woon ChoiJin A ShinMDPI AGarticleretinal ganglion cellstatinglaucomaneuroprotectionocular hypertensionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12500, p 12500 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal ganglion cell statin glaucoma neuroprotection ocular hypertension Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	retinal ganglion cell statin glaucoma neuroprotection ocular hypertension Biology (General) QH301-705.5 Chemistry QD1-999 Mi-Lyang Kim Kyung Rim Sung Junki Kwon Go Woon Choi Jin A Shin Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
description	Glaucoma is an optic neuropathy in which the degeneration of retinal ganglion cells (RGCs) results in irreversible vison loss. Therefore, neuroprotection of RGCs from glaucomatous afflictions is crucial for glaucoma treatment. In this study, we aimed to investigate the beneficial effects of statins in the protection of RGCs using a rat model. Glaucomatous injury was induced in rats by chronic ocular hypertension (OHT) achieved after performing a circumlimbal suture. The rats were given either statins such as simvastatin and atorvastatin or a solvent weekly for 6 weeks. Retina sections underwent hematoxylin and eosin, Brn3a, or cleaved casepase-3 staining to evaluate RGC survival. In addition, modulation of glial activation was assessed. While the retinas without statin treatment exhibited increased RGC death due to chronic OHT, statins promoted the survival of RGCs and reduced apoptosis. Statins also suppressed chronic OHT-mediated glial activation in the retina. Our results demonstrate that statins exert neuroprotective effects in rat retinas exposed to chronic OHT, which may support the prospect of statins being a glaucoma treatment.
format	article
author	Mi-Lyang Kim Kyung Rim Sung Junki Kwon Go Woon Choi Jin A Shin
author_facet	Mi-Lyang Kim Kyung Rim Sung Junki Kwon Go Woon Choi Jin A Shin
author_sort	Mi-Lyang Kim
title	Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
title_short	Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
title_full	Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
title_fullStr	Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
title_full_unstemmed	Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension
title_sort	neuroprotective effect of statins in a rat model of chronic ocular hypertension
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c4801c941ff54baea351cff86f4deb7e
work_keys_str_mv	AT milyangkim neuroprotectiveeffectofstatinsinaratmodelofchronicocularhypertension AT kyungrimsung neuroprotectiveeffectofstatinsinaratmodelofchronicocularhypertension AT junkikwon neuroprotectiveeffectofstatinsinaratmodelofchronicocularhypertension AT gowoonchoi neuroprotectiveeffectofstatinsinaratmodelofchronicocularhypertension AT jinashin neuroprotectiveeffectofstatinsinaratmodelofchronicocularhypertension
_version_	1718411827678806016

Neuroprotective Effect of Statins in a Rat Model of Chronic Ocular Hypertension

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