Two Duplicated Ptpn6 Homeologs Cooperatively and Negatively Regulate RLR-Mediated IFN Response in Hexaploid Gibel Carp

Two Duplicated Ptpn6 Homeologs Cooperatively and Negatively Regulate RLR-Mediated IFN Response in Hexaploid Gibel Carp

Src homology region 2 domain-containing phosphatase 1 (SHP1), encoded by the protein tyrosine phosphatase nonreceptor type 6 (ptpn6) gene, belongs to the family of protein tyrosine phosphatases (PTPs) and participates in multiple signaling pathways of immune cells. However, the mechanism of SHP1 in...

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Auteurs principaux: Jin-Feng Tong, Li Zhou, Shun Li, Long-Feng Lu, Zhuo-Cong Li, Zhi Li, Rui-Hai Gan, Cheng-Yan Mou, Qi-Ya Zhang, Zhong-Wei Wang, Xiao-Juan Zhang, Yang Wang, Jian-Fang Gui
Format: article
Langue:EN
Publié: Frontiers Media S.A. 2021
Sujets:
Gibel carp
SHP1
negative regulator
autophagy
MITA
interferon
Immunologic diseases. Allergy
RC581-607
Accès en ligne:https://doaj.org/article/c48623879e57447aaf7fb347b836bc28
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https://doaj.org/article/c48623879e57447aaf7fb347b836bc28

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