BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder

Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met...

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Autores principales:	Caroline Ferreira Fratelli, Jhon Willatan Siqueira, Bruna Rodrigues Gontijo, Maurício de Lima Santos, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Silva
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c48663e8a45448449f0bf319ad5e8863
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spelling	oai:doaj.org-article:c48663e8a45448449f0bf319ad5e88632021-11-15T01:19:20ZBDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder1875-858410.1155/2021/7117613https://doaj.org/article/c48663e8a45448449f0bf319ad5e88632021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7117613https://doaj.org/toc/1875-8584Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients.Caroline Ferreira FratelliJhon Willatan SiqueiraBruna Rodrigues GontijoMaurício de Lima SantosCalliandra Maria de Souza SilvaIzabel Cristina Rodrigues da SilvaHindawi LimitedarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBehavioural Neurology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Caroline Ferreira Fratelli Jhon Willatan Siqueira Bruna Rodrigues Gontijo Maurício de Lima Santos Calliandra Maria de Souza Silva Izabel Cristina Rodrigues da Silva BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
description	Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients.
format	article
author	Caroline Ferreira Fratelli Jhon Willatan Siqueira Bruna Rodrigues Gontijo Maurício de Lima Santos Calliandra Maria de Souza Silva Izabel Cristina Rodrigues da Silva
author_facet	Caroline Ferreira Fratelli Jhon Willatan Siqueira Bruna Rodrigues Gontijo Maurício de Lima Santos Calliandra Maria de Souza Silva Izabel Cristina Rodrigues da Silva
author_sort	Caroline Ferreira Fratelli
title	BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
title_short	BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
title_full	BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
title_fullStr	BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
title_full_unstemmed	BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder
title_sort	bdnf genetic variant and its genotypic fluctuation in major depressive disorder
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/c48663e8a45448449f0bf319ad5e8863
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BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder

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