DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.

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Autores principales:	Markus Sauer, Stefan A. Juranek, James Marks, Alessio De Magis, Hinke G. Kazemier, Daniel Hilbig, Daniel Benhalevy, Xiantao Wang, Markus Hafner, Katrin Paeschke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c487ca0e9f33481f9ed1636cdf7e8cc9
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spelling	oai:doaj.org-article:c487ca0e9f33481f9ed1636cdf7e8cc92021-12-02T14:39:38ZDHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions10.1038/s41467-019-10432-52041-1723https://doaj.org/article/c487ca0e9f33481f9ed1636cdf7e8cc92019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10432-5https://doaj.org/toc/2041-1723Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.Markus SauerStefan A. JuranekJames MarksAlessio De MagisHinke G. KazemierDaniel HilbigDaniel BenhalevyXiantao WangMarkus HafnerKatrin PaeschkeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
description	Translation efficiency can be affected by mRNA stability and secondary RNA structures. Here the authors reveal that loss of DHX36 helicase activity leads to an accumulation of translationally inactive target mRNAs with G-rich structures in untranslated regions.
format	article
author	Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke
author_facet	Markus Sauer Stefan A. Juranek James Marks Alessio De Magis Hinke G. Kazemier Daniel Hilbig Daniel Benhalevy Xiantao Wang Markus Hafner Katrin Paeschke
author_sort	Markus Sauer
title	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_short	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_full	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_fullStr	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_full_unstemmed	DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions
title_sort	dhx36 prevents the accumulation of translationally inactive mrnas with g4-structures in untranslated regions
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c487ca0e9f33481f9ed1636cdf7e8cc9
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DHX36 prevents the accumulation of translationally inactive mRNAs with G4-structures in untranslated regions

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