Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat

Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing activity in higher-order prefrontal cognitive region...

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Autores principales: Laith Alexander, Christian M. Wood, Philip L. R. Gaskin, Stephen J. Sawiak, Tim D. Fryer, Young T. Hong, Lauren McIver, Hannah F. Clarke, Angela C. Roberts
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c4882c5246f44a9f9ba8c63aa0cd943b
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Sumario:Alexander et al. causally implicate over-activity in primate subgenual cingulate in affective and cardiovascular dysfunction relevant to anxiety and depression. Over-activation led to elevated activity in a stress-related network whilst decreasing activity in higher-order prefrontal cognitive regions.