Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study

Abstract Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an objective approach. A total of 106 post-CPR patients were included in this single-center observational prospective study. Serum sST2 leve...

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Autores principales:	Richard Rezar, Vera Paar, Clemens Seelmaier, Ingrid Pretsch, Philipp Schwaiger, Kristen Kopp, Reinhard Kaufmann, Thomas K. Felder, Erika Prinz, Geza Gemes, Rudin Pistulli, Uta C. Hoppe, Bernhard Wernly, Michael Lichtenauer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c488579bf13241ada642ea52b08886ad
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spelling	oai:doaj.org-article:c488579bf13241ada642ea52b08886ad2021-11-08T10:48:39ZSoluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study10.1038/s41598-021-01389-x2045-2322https://doaj.org/article/c488579bf13241ada642ea52b08886ad2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01389-xhttps://doaj.org/toc/2045-2322Abstract Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an objective approach. A total of 106 post-CPR patients were included in this single-center observational prospective study. Serum sST2 levels were obtained 24 h after admission. Individuals were assigned to two groups: patients below and above the overall cohort’s median sST2 concentration. Primary outcome was a combined endpoint at 6 months (death or Cerebral Performance Category > 2); secondary endpoint 30-day mortality. A uni- and multivariate logistic regression analysis were conducted. Elevated sST2-levels were associated with an increased risk for the primary outcome (OR 1.011, 95% CI 1.004–1.019, p = 0.004), yet no patients with poor neurological outcome were observed at 6 months. The optimal empirical cut-off for sST2 was 46.15 ng/ml (sensitivity 81%, specificity 53%, AUC 0.69). Levels above the median (> 53.42 ng/ml) were associated with higher odds for both endpoints (death or CPC > 2 after 6 months: 21% vs. 49%, OR 3.59, 95% CI 1.53–8.45, p = 0.003; death after 30 days: 17% vs. 43.3%, OR 3.75, 95% CI 1.52–9.21, p = 0.003). A positive correlation of serum sST2 after CPR with mortality at 30 days and 6 months after cardiac arrest could be demonstrated.Richard RezarVera PaarClemens SeelmaierIngrid PretschPhilipp SchwaigerKristen KoppReinhard KaufmannThomas K. FelderErika PrinzGeza GemesRudin PistulliUta C. HoppeBernhard WernlyMichael LichtenauerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Richard Rezar Vera Paar Clemens Seelmaier Ingrid Pretsch Philipp Schwaiger Kristen Kopp Reinhard Kaufmann Thomas K. Felder Erika Prinz Geza Gemes Rudin Pistulli Uta C. Hoppe Bernhard Wernly Michael Lichtenauer Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
description	Abstract Prognostication after cardiopulmonary resuscitation (CPR) is complex. Novel biomarkers like soluble suppression of tumorigenicity 2 (sST2) may provide an objective approach. A total of 106 post-CPR patients were included in this single-center observational prospective study. Serum sST2 levels were obtained 24 h after admission. Individuals were assigned to two groups: patients below and above the overall cohort’s median sST2 concentration. Primary outcome was a combined endpoint at 6 months (death or Cerebral Performance Category > 2); secondary endpoint 30-day mortality. A uni- and multivariate logistic regression analysis were conducted. Elevated sST2-levels were associated with an increased risk for the primary outcome (OR 1.011, 95% CI 1.004–1.019, p = 0.004), yet no patients with poor neurological outcome were observed at 6 months. The optimal empirical cut-off for sST2 was 46.15 ng/ml (sensitivity 81%, specificity 53%, AUC 0.69). Levels above the median (> 53.42 ng/ml) were associated with higher odds for both endpoints (death or CPC > 2 after 6 months: 21% vs. 49%, OR 3.59, 95% CI 1.53–8.45, p = 0.003; death after 30 days: 17% vs. 43.3%, OR 3.75, 95% CI 1.52–9.21, p = 0.003). A positive correlation of serum sST2 after CPR with mortality at 30 days and 6 months after cardiac arrest could be demonstrated.
format	article
author	Richard Rezar Vera Paar Clemens Seelmaier Ingrid Pretsch Philipp Schwaiger Kristen Kopp Reinhard Kaufmann Thomas K. Felder Erika Prinz Geza Gemes Rudin Pistulli Uta C. Hoppe Bernhard Wernly Michael Lichtenauer
author_facet	Richard Rezar Vera Paar Clemens Seelmaier Ingrid Pretsch Philipp Schwaiger Kristen Kopp Reinhard Kaufmann Thomas K. Felder Erika Prinz Geza Gemes Rudin Pistulli Uta C. Hoppe Bernhard Wernly Michael Lichtenauer
author_sort	Richard Rezar
title	Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
title_short	Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
title_full	Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
title_fullStr	Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
title_full_unstemmed	Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
title_sort	soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c488579bf13241ada642ea52b08886ad
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Soluble suppression of tumorigenicity 2 as outcome predictor after cardiopulmonary resuscitation: an observational prospective study

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