Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic

Surface antimicrobial materials are of interest as they can combat the critical threat of microbial contamination without contributing to issues of environmental contamination and the development drug resistance. Most nanostructured surfaces are prepared by post fabrication modifications and activel...

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Autores principales:	Shook Pui Chan, Diane S. W. Lim, Arunmozhiarasi Armugam, Guangshun Yi, Yugen Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial plastic sustainable material surface phase seperation surface nanostructure semi-free polyionic Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c488749bcb174856951fba9ea883cff7
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spelling	oai:doaj.org-article:c488749bcb174856951fba9ea883cff72021-11-25T17:55:21ZSoft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic10.3390/ijms2222123151422-00671661-6596https://doaj.org/article/c488749bcb174856951fba9ea883cff72021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12315https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Surface antimicrobial materials are of interest as they can combat the critical threat of microbial contamination without contributing to issues of environmental contamination and the development drug resistance. Most nanostructured surfaces are prepared by post fabrication modifications and actively release antimicrobial agents. These properties limit the potential applications of nanostructured materials on flexible surfaces. Here, we report on an easily synthesized plastic material with inherent antimicrobial activity, demonstrating excellent microbicidal properties against common bacteria and fungus. The plastic material did not release antimicrobial components as they were anchored to the polymer chains via strong covalent bonds. Time-kill kinetics studies have shown that bactericidal effects take place when bacteria come into contact with a material for a prolonged period, resulting in the deformation and rupture of bacteria cells. A scanning probe microscopy analysis revealed soft nanostructures on the submicron scale, for which the formation is thought to occur via surface phase separation. These soft nanostructures allow for polyionic antimicrobial components to be present on the surface, where they freely interact with and kill microbes. Overall, the new green and sustainable plastic is easily synthesized and demonstrates inherent and long-lasting activity without toxic chemical leaching.Shook Pui ChanDiane S. W. LimArunmozhiarasi ArmugamGuangshun YiYugen ZhangMDPI AGarticleantimicrobial plasticsustainable materialsurface phase seperationsurface nanostructuresemi-free polyionicBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12315, p 12315 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial plastic sustainable material surface phase seperation surface nanostructure semi-free polyionic Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antimicrobial plastic sustainable material surface phase seperation surface nanostructure semi-free polyionic Biology (General) QH301-705.5 Chemistry QD1-999 Shook Pui Chan Diane S. W. Lim Arunmozhiarasi Armugam Guangshun Yi Yugen Zhang Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
description	Surface antimicrobial materials are of interest as they can combat the critical threat of microbial contamination without contributing to issues of environmental contamination and the development drug resistance. Most nanostructured surfaces are prepared by post fabrication modifications and actively release antimicrobial agents. These properties limit the potential applications of nanostructured materials on flexible surfaces. Here, we report on an easily synthesized plastic material with inherent antimicrobial activity, demonstrating excellent microbicidal properties against common bacteria and fungus. The plastic material did not release antimicrobial components as they were anchored to the polymer chains via strong covalent bonds. Time-kill kinetics studies have shown that bactericidal effects take place when bacteria come into contact with a material for a prolonged period, resulting in the deformation and rupture of bacteria cells. A scanning probe microscopy analysis revealed soft nanostructures on the submicron scale, for which the formation is thought to occur via surface phase separation. These soft nanostructures allow for polyionic antimicrobial components to be present on the surface, where they freely interact with and kill microbes. Overall, the new green and sustainable plastic is easily synthesized and demonstrates inherent and long-lasting activity without toxic chemical leaching.
format	article
author	Shook Pui Chan Diane S. W. Lim Arunmozhiarasi Armugam Guangshun Yi Yugen Zhang
author_facet	Shook Pui Chan Diane S. W. Lim Arunmozhiarasi Armugam Guangshun Yi Yugen Zhang
author_sort	Shook Pui Chan
title	Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
title_short	Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
title_full	Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
title_fullStr	Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
title_full_unstemmed	Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic
title_sort	soft surface nanostructure with semi-free polyionic components for sustainable antimicrobial plastic
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c488749bcb174856951fba9ea883cff7
work_keys_str_mv	AT shookpuichan softsurfacenanostructurewithsemifreepolyioniccomponentsforsustainableantimicrobialplastic AT dianeswlim softsurfacenanostructurewithsemifreepolyioniccomponentsforsustainableantimicrobialplastic AT arunmozhiarasiarmugam softsurfacenanostructurewithsemifreepolyioniccomponentsforsustainableantimicrobialplastic AT guangshunyi softsurfacenanostructurewithsemifreepolyioniccomponentsforsustainableantimicrobialplastic AT yugenzhang softsurfacenanostructurewithsemifreepolyioniccomponentsforsustainableantimicrobialplastic
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Soft Surface Nanostructure with Semi-Free Polyionic Components for Sustainable Antimicrobial Plastic

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