Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations

Abstract Our previous work reported the association between two single nucleotide polymorphisms (SNPs) in PIN1 promoter and nasopharyngeal carcinoma (NPC) risk with a small sample size in a low incidence area. This study investigated the association between the two SNPs and NPC risk in 733 patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liuyan Zeng, Shengqun Luo, Xin Li, Mengxuan Lu, Huahui Li, Tong Li, Guanhua Wang, Xiaoming Lyu, Wenrui Jia, Zigang Dong, Qiang Jiang, Zhihua Shen, Guo-Liang Huang, Zhiwei He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c48bde0a6ecb44149fd93cfe2716c4e6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c48bde0a6ecb44149fd93cfe2716c4e6
record_format	dspace
spelling	oai:doaj.org-article:c48bde0a6ecb44149fd93cfe2716c4e62021-12-02T15:05:49ZFunctional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations10.1038/s41598-017-04156-z2045-2322https://doaj.org/article/c48bde0a6ecb44149fd93cfe2716c4e62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04156-zhttps://doaj.org/toc/2045-2322Abstract Our previous work reported the association between two single nucleotide polymorphisms (SNPs) in PIN1 promoter and nasopharyngeal carcinoma (NPC) risk with a small sample size in a low incidence area. This study investigated the association between the two SNPs and NPC risk in 733 patients and 895 controls from a high incidence area. The results indicated the genotype and allele frequencies of -842G > C and -667C > T were both significantly different between patients and controls even using the resampling statistics. The -842GC and -667TT genotypes showed a significantly increased risk of NPC (OR = 1.977, 95% CI = 1.339–2.919, P = 0.001 and OR = 1.438, 95% CI = 1.061–1.922, P = 0.019, respectively). Compared to the most common -842G-667C haplotype, -842G-667T haplotype and -842C-667C haplotype showed a significantly increased risk of NPC (OR = 1.215, 95% CI = 1.053–1.402, P = 0.008 and OR = 2.268, 95% CI = 1.530–3.362, P = 0.001, respectively). Further reporter gene expression suggested that variant -842C-667C and -842G-667T were associated with an enhanced transcriptional activity. In conclusion, our findings suggest that -842G > C and -667C > T in PIN1 promoter are associated with NPC risk; as well as the promoter activity is mediated by functional PIN1 variants.Liuyan ZengShengqun LuoXin LiMengxuan LuHuahui LiTong LiGuanhua WangXiaoming LyuWenrui JiaZigang DongQiang JiangZhihua ShenGuo-Liang HuangZhiwei HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liuyan Zeng Shengqun Luo Xin Li Mengxuan Lu Huahui Li Tong Li Guanhua Wang Xiaoming Lyu Wenrui Jia Zigang Dong Qiang Jiang Zhihua Shen Guo-Liang Huang Zhiwei He Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
description	Abstract Our previous work reported the association between two single nucleotide polymorphisms (SNPs) in PIN1 promoter and nasopharyngeal carcinoma (NPC) risk with a small sample size in a low incidence area. This study investigated the association between the two SNPs and NPC risk in 733 patients and 895 controls from a high incidence area. The results indicated the genotype and allele frequencies of -842G > C and -667C > T were both significantly different between patients and controls even using the resampling statistics. The -842GC and -667TT genotypes showed a significantly increased risk of NPC (OR = 1.977, 95% CI = 1.339–2.919, P = 0.001 and OR = 1.438, 95% CI = 1.061–1.922, P = 0.019, respectively). Compared to the most common -842G-667C haplotype, -842G-667T haplotype and -842C-667C haplotype showed a significantly increased risk of NPC (OR = 1.215, 95% CI = 1.053–1.402, P = 0.008 and OR = 2.268, 95% CI = 1.530–3.362, P = 0.001, respectively). Further reporter gene expression suggested that variant -842C-667C and -842G-667T were associated with an enhanced transcriptional activity. In conclusion, our findings suggest that -842G > C and -667C > T in PIN1 promoter are associated with NPC risk; as well as the promoter activity is mediated by functional PIN1 variants.
format	article
author	Liuyan Zeng Shengqun Luo Xin Li Mengxuan Lu Huahui Li Tong Li Guanhua Wang Xiaoming Lyu Wenrui Jia Zigang Dong Qiang Jiang Zhihua Shen Guo-Liang Huang Zhiwei He
author_facet	Liuyan Zeng Shengqun Luo Xin Li Mengxuan Lu Huahui Li Tong Li Guanhua Wang Xiaoming Lyu Wenrui Jia Zigang Dong Qiang Jiang Zhihua Shen Guo-Liang Huang Zhiwei He
author_sort	Liuyan Zeng
title	Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
title_short	Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
title_full	Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
title_fullStr	Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
title_full_unstemmed	Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations
title_sort	functional pin1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in southern chinese populations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c48bde0a6ecb44149fd93cfe2716c4e6
work_keys_str_mv	AT liuyanzeng functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT shengqunluo functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT xinli functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT mengxuanlu functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT huahuili functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT tongli functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT guanhuawang functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT xiaominglyu functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT wenruijia functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT zigangdong functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT qiangjiang functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT zhihuashen functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT guolianghuang functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations AT zhiweihe functionalpin1promoterpolymorphismsassociatedwithriskofnasopharyngealcarcinomainsouthernchinesepopulations
_version_	1718388731600175104

Functional PIN1 promoter polymorphisms associated with risk of nasopharyngeal carcinoma in Southern Chinese populations

Ejemplares similares