Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain

Abstract The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of...

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Autores principales:	Marat I. Airapetov, Sergei O. Eresko, Andrei A. Lebedev, Evgenii R. Bychkov, Petr D. Shabanov
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	brain ghrelin GHS‐R1a Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c48f087da9ee405bb2ef0f0fe985c013
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spelling	oai:doaj.org-article:c48f087da9ee405bb2ef0f0fe985c0132021-11-15T09:54:40ZExpression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain2051-817X10.14814/phy2.15113https://doaj.org/article/c48f087da9ee405bb2ef0f0fe985c0132021-11-01T00:00:00Zhttps://doi.org/10.14814/phy2.15113https://doaj.org/toc/2051-817XAbstract The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of the receptor in many physiological processes. Using various organisms, data have been obtained regarding the participation of the GHS‐R1a in the regulation of the anti‐ and pro‐inflammatory response, proliferation, and apoptosis. It is known that the receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of drug addiction, obesity, and chronic alcohol consumption. Based on this, research is underway with the use of various therapeutic agents that can be used for the pharmacological correction of these conditions. This review also presents hypothetical pathways of intracellular signaling, in which GHS‐R1a may participate. A complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular signaling seem to be specific to brain region and, probably, also depend on the metabolic or stress status of the organism.Marat I. AirapetovSergei O. EreskoAndrei A. LebedevEvgenii R. BychkovPetr D. ShabanovWileyarticlebrainghrelinGHS‐R1aPhysiologyQP1-981ENPhysiological Reports, Vol 9, Iss 21, Pp n/a-n/a (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain ghrelin GHS‐R1a Physiology QP1-981
spellingShingle	brain ghrelin GHS‐R1a Physiology QP1-981 Marat I. Airapetov Sergei O. Eresko Andrei A. Lebedev Evgenii R. Bychkov Petr D. Shabanov Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
description	Abstract The review presents data on the expression of growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain regions in model animals (zebrafish, rodents, primates), and in the human brain. Studies show widespread distribution of the receptor in the brain, which evidences the involvement of the receptor in many physiological processes. Using various organisms, data have been obtained regarding the participation of the GHS‐R1a in the regulation of the anti‐ and pro‐inflammatory response, proliferation, and apoptosis. It is known that the receptor plays an important role in eating behavior and is also involved in the pathogenetic mechanisms of drug addiction, obesity, and chronic alcohol consumption. Based on this, research is underway with the use of various therapeutic agents that can be used for the pharmacological correction of these conditions. This review also presents hypothetical pathways of intracellular signaling, in which GHS‐R1a may participate. A complete understanding of these mechanisms has not yet been reached. The ghrelin intracellular signaling seem to be specific to brain region and, probably, also depend on the metabolic or stress status of the organism.
format	article
author	Marat I. Airapetov Sergei O. Eresko Andrei A. Lebedev Evgenii R. Bychkov Petr D. Shabanov
author_facet	Marat I. Airapetov Sergei O. Eresko Andrei A. Lebedev Evgenii R. Bychkov Petr D. Shabanov
author_sort	Marat I. Airapetov
title	Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
title_short	Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
title_full	Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
title_fullStr	Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
title_full_unstemmed	Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain
title_sort	expression of the growth hormone secretagogue receptor 1a (ghs‐r1a) in the brain
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/c48f087da9ee405bb2ef0f0fe985c013
work_keys_str_mv	AT maratiairapetov expressionofthegrowthhormonesecretagoguereceptor1aghsr1ainthebrain AT sergeioeresko expressionofthegrowthhormonesecretagoguereceptor1aghsr1ainthebrain AT andreialebedev expressionofthegrowthhormonesecretagoguereceptor1aghsr1ainthebrain AT evgeniirbychkov expressionofthegrowthhormonesecretagoguereceptor1aghsr1ainthebrain AT petrdshabanov expressionofthegrowthhormonesecretagoguereceptor1aghsr1ainthebrain
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Expression of the growth hormone secretagogue receptor 1a (GHS‐R1a) in the brain

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