Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness

Mental disorders are heterogeneous and psychiatric comorbidities are common. Previous studies have suggested a link between inflammation and mental disorders. This link can manifest as increased levels of proinflammatory mediators in circulation and as signs of neuroinflammation. Furthermore, there...

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Autores principales:	Ulrika Hylén, Aidan McGlinchey, Matej Orešič, Susanne Bejerot, Mats B. Humble, Eva Särndahl, Tuulia Hyötyläinen, Daniel Eklund
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mental disorder (disease) schizophrenia autism spectrum disorder (ASD) obsessive-compulsive disorder lipidomics inflammation Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/c48f5291f1af45d6bd110d97e565871b
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spelling	oai:doaj.org-article:c48f5291f1af45d6bd110d97e565871b2021-12-01T07:06:09ZPotential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness1664-064010.3389/fpsyt.2021.778325https://doaj.org/article/c48f5291f1af45d6bd110d97e565871b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.778325/fullhttps://doaj.org/toc/1664-0640Mental disorders are heterogeneous and psychiatric comorbidities are common. Previous studies have suggested a link between inflammation and mental disorders. This link can manifest as increased levels of proinflammatory mediators in circulation and as signs of neuroinflammation. Furthermore, there is strong evidence that individuals suffering from psychiatric disorders have increased risk of developing metabolic comorbidities. Our group has previously shown that, in a cohort of low-functioning individuals with serious mental disorders, there is increased expression of genes associated with the NLRP3 inflammasome, a known sensor of metabolic perturbations, as well as increased levels of IL-1-family cytokines. In the current study, we set out to explore the interplay between disease-specific changes in lipid metabolism and known markers of inflammation. To this end, we performed mass spectrometry-based lipidomic analysis of plasma samples from low-functioning individuals with serious mental disorders (n = 39) and matched healthy controls (n = 39). By identifying non-spurious immune-lipid associations, we derived a partial correlation network of inflammatory markers and molecular lipids. We identified levels of lipids as being altered between individuals with serious mental disorders and controls, showing associations between lipids and inflammatory mediators, e.g., osteopontin and IL-1 receptor antagonist. These results indicate that, in low-functioning individuals with serious mental disorders, changes in specific lipids associate with immune mediators that are known to affect neuroinflammatory diseases.Ulrika HylénUlrika HylénUlrika HylénAidan McGlincheyMatej OrešičSusanne BejerotSusanne BejerotSusanne BejerotMats B. HumbleMats B. HumbleEva SärndahlEva SärndahlTuulia HyötyläinenDaniel EklundDaniel EklundFrontiers Media S.A.articlemental disorder (disease)schizophreniaautism spectrum disorder (ASD)obsessive-compulsive disorderlipidomicsinflammationPsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mental disorder (disease) schizophrenia autism spectrum disorder (ASD) obsessive-compulsive disorder lipidomics inflammation Psychiatry RC435-571
spellingShingle	mental disorder (disease) schizophrenia autism spectrum disorder (ASD) obsessive-compulsive disorder lipidomics inflammation Psychiatry RC435-571 Ulrika Hylén Ulrika Hylén Ulrika Hylén Aidan McGlinchey Matej Orešič Susanne Bejerot Susanne Bejerot Susanne Bejerot Mats B. Humble Mats B. Humble Eva Särndahl Eva Särndahl Tuulia Hyötyläinen Daniel Eklund Daniel Eklund Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
description	Mental disorders are heterogeneous and psychiatric comorbidities are common. Previous studies have suggested a link between inflammation and mental disorders. This link can manifest as increased levels of proinflammatory mediators in circulation and as signs of neuroinflammation. Furthermore, there is strong evidence that individuals suffering from psychiatric disorders have increased risk of developing metabolic comorbidities. Our group has previously shown that, in a cohort of low-functioning individuals with serious mental disorders, there is increased expression of genes associated with the NLRP3 inflammasome, a known sensor of metabolic perturbations, as well as increased levels of IL-1-family cytokines. In the current study, we set out to explore the interplay between disease-specific changes in lipid metabolism and known markers of inflammation. To this end, we performed mass spectrometry-based lipidomic analysis of plasma samples from low-functioning individuals with serious mental disorders (n = 39) and matched healthy controls (n = 39). By identifying non-spurious immune-lipid associations, we derived a partial correlation network of inflammatory markers and molecular lipids. We identified levels of lipids as being altered between individuals with serious mental disorders and controls, showing associations between lipids and inflammatory mediators, e.g., osteopontin and IL-1 receptor antagonist. These results indicate that, in low-functioning individuals with serious mental disorders, changes in specific lipids associate with immune mediators that are known to affect neuroinflammatory diseases.
format	article
author	Ulrika Hylén Ulrika Hylén Ulrika Hylén Aidan McGlinchey Matej Orešič Susanne Bejerot Susanne Bejerot Susanne Bejerot Mats B. Humble Mats B. Humble Eva Särndahl Eva Särndahl Tuulia Hyötyläinen Daniel Eklund Daniel Eklund
author_facet	Ulrika Hylén Ulrika Hylén Ulrika Hylén Aidan McGlinchey Matej Orešič Susanne Bejerot Susanne Bejerot Susanne Bejerot Mats B. Humble Mats B. Humble Eva Särndahl Eva Särndahl Tuulia Hyötyläinen Daniel Eklund Daniel Eklund
author_sort	Ulrika Hylén
title	Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
title_short	Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
title_full	Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
title_fullStr	Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
title_full_unstemmed	Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness
title_sort	potential transdiagnostic lipid mediators of inflammatory activity in individuals with serious mental illness
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c48f5291f1af45d6bd110d97e565871b
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Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness

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