Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)

Introduction: Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their...

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Autores principales: A Vancappel, Y Dansou, O Godin, E Haffen, A Yrondi, F Stéphan, R Richieri, F Molière, M Horn, E Allauze, JB Genty, A Bouvard, JM Dorey, M Meyrel, V Camus, G Fond, B Péran, M Walter, L Anguill, C Scotto d'Apollonia, AS Nguon, B Fredembach, J Holtzmann, E Vilà, J Petrucci, Rey, B Etain, M Carminati, P Courtet, G Vaiva, PM Llorca, M Leboyer, B Aouizerate, D Bennabi, W El-Hage
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Publicado: Elsevier 2021
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spelling oai:doaj.org-article:c4929835b71b4e499aac1b6cfde37a1c2021-11-26T04:42:00ZCognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)2666-915310.1016/j.jadr.2021.100272https://doaj.org/article/c4929835b71b4e499aac1b6cfde37a1c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666915321001943https://doaj.org/toc/2666-9153Introduction: Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method: We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results: TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion: Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.A VancappelY DansouO GodinE HaffenA YrondiF StéphanR RichieriF MolièreM HornE AllauzeJB GentyA BouvardJM DoreyM MeyrelV CamusG FondB PéranM WalterL AnguillC Scotto d'ApolloniaAS NguonB FredembachJ HoltzmannE VilàJ Petrucci ReyB EtainM CarminatiP CourtetG VaivaPM LlorcaM LeboyerB AouizerateD BennabiW El-HageElsevierarticleTreatment resistant depressionCognitive impairmentsNeuropsychologyMemoryExecutive functionProcessing speedMental healingRZ400-408ENJournal of Affective Disorders Reports, Vol 6, Iss , Pp 100272- (2021)
institution DOAJ
collection DOAJ
language EN
topic Treatment resistant depression
Cognitive impairments
Neuropsychology
Memory
Executive function
Processing speed
Mental healing
RZ400-408
spellingShingle Treatment resistant depression
Cognitive impairments
Neuropsychology
Memory
Executive function
Processing speed
Mental healing
RZ400-408
A Vancappel
Y Dansou
O Godin
E Haffen
A Yrondi
F Stéphan
R Richieri
F Molière
M Horn
E Allauze
JB Genty
A Bouvard
JM Dorey
M Meyrel
V Camus
G Fond
B Péran
M Walter
L Anguill
C Scotto d'Apollonia
AS Nguon
B Fredembach
J Holtzmann
E Vilà
J Petrucci
Rey
B Etain
M Carminati
P Courtet
G Vaiva
PM Llorca
M Leboyer
B Aouizerate
D Bennabi
W El-Hage
Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
description Introduction: Previous studies set out cognitive impairments in major depression. However, only two studies were performed among patients suffering from treatment-resistant depression (TRD) and conducted on limited sample sizes. Here, we aimed to characterize cognitive impairments in TRD, and their association with the severity of depression and daily functioning. Method: We included 288 patients suffering from TRD (178 women, 52.5 ± 13.1 years old). They undertook sociodemographic, clinical, daily functioning and neuropsychological testing (TMT, Baddeley task, verbal fluencies, WAIS-4 subtests, D2 and RLRI-16). We compared our patients’ performances to theoretical performances of the general population. Results: TRD was associated with poorer neuropsychological performances, except for similarities task. We found an effect of depression severity on processing speed and memory, and an impact on daily functioning affecting memory, selective attention and executive function. Conclusion: Patients suffering from TRD have significant cognitive impairments. Therapeutic interventions should be developed to manage such impairments.
format article
author A Vancappel
Y Dansou
O Godin
E Haffen
A Yrondi
F Stéphan
R Richieri
F Molière
M Horn
E Allauze
JB Genty
A Bouvard
JM Dorey
M Meyrel
V Camus
G Fond
B Péran
M Walter
L Anguill
C Scotto d'Apollonia
AS Nguon
B Fredembach
J Holtzmann
E Vilà
J Petrucci
Rey
B Etain
M Carminati
P Courtet
G Vaiva
PM Llorca
M Leboyer
B Aouizerate
D Bennabi
W El-Hage
author_facet A Vancappel
Y Dansou
O Godin
E Haffen
A Yrondi
F Stéphan
R Richieri
F Molière
M Horn
E Allauze
JB Genty
A Bouvard
JM Dorey
M Meyrel
V Camus
G Fond
B Péran
M Walter
L Anguill
C Scotto d'Apollonia
AS Nguon
B Fredembach
J Holtzmann
E Vilà
J Petrucci
Rey
B Etain
M Carminati
P Courtet
G Vaiva
PM Llorca
M Leboyer
B Aouizerate
D Bennabi
W El-Hage
author_sort A Vancappel
title Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
title_short Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
title_full Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
title_fullStr Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
title_full_unstemmed Cognitive impairments in treatment-resistant depression: Results from the French cohort of outpatients (FACE-DR)
title_sort cognitive impairments in treatment-resistant depression: results from the french cohort of outpatients (face-dr)
publisher Elsevier
publishDate 2021
url https://doaj.org/article/c4929835b71b4e499aac1b6cfde37a1c
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