Daily circadian misalignment impairs human cognitive performance task-dependently

Abstract Shift work increases the risk for human errors, such that drowsiness due to shift work has contributed to major industrial disasters, including Space Shuttle Challenger, Chernobyl and Alaska Oil Spill disasters, with extraordinary socio-economical costs. Overnight operations pose a challeng...

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Autores principales:	Sarah L. Chellappa, Christopher J. Morris, Frank A. J. L. Scheer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4942092090441c499646489cff8c7e0
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spelling	oai:doaj.org-article:c4942092090441c499646489cff8c7e02021-12-02T15:09:11ZDaily circadian misalignment impairs human cognitive performance task-dependently10.1038/s41598-018-20707-42045-2322https://doaj.org/article/c4942092090441c499646489cff8c7e02018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20707-4https://doaj.org/toc/2045-2322Abstract Shift work increases the risk for human errors, such that drowsiness due to shift work has contributed to major industrial disasters, including Space Shuttle Challenger, Chernobyl and Alaska Oil Spill disasters, with extraordinary socio-economical costs. Overnight operations pose a challenge because our circadian biology inhibits cognitive performance at night. Yet how the circadian system modulates cognition over multiple days under realistic shift work conditions remains to be established. Importantly, because task-specific cognitive brain regions show different 24-h circadian dynamics, we hypothesize that circadian misalignment impacts cognition task-dependently. Using a biologically-driven paradigm mimicking night shift work, with a randomized, cross-over design, we show that misalignment between the circadian pacemaker and behavioral/environmental cycles increases cognitive vulnerability on sustained attention, cognitive throughput, information processing and visual-motor performance over multiple days, compared to circadian alignment (day shifts). Circadian misalignment effects are task-dependent: while they acutely impair sustained attention with recovery after 3-days, they progressively hinder daily learning. Individuals felt sleepier during circadian misalignment, but they did not rate their performance as worse. Furthermore, circadian misalignment effects on sustained attention depended on prior sleep history. Collectively, daily circadian misalignment may provide an important biological framework for developing countermeasures against adverse cognitive effects in shift workers.Sarah L. ChellappaChristopher J. MorrisFrank A. J. L. ScheerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sarah L. Chellappa Christopher J. Morris Frank A. J. L. Scheer Daily circadian misalignment impairs human cognitive performance task-dependently
description	Abstract Shift work increases the risk for human errors, such that drowsiness due to shift work has contributed to major industrial disasters, including Space Shuttle Challenger, Chernobyl and Alaska Oil Spill disasters, with extraordinary socio-economical costs. Overnight operations pose a challenge because our circadian biology inhibits cognitive performance at night. Yet how the circadian system modulates cognition over multiple days under realistic shift work conditions remains to be established. Importantly, because task-specific cognitive brain regions show different 24-h circadian dynamics, we hypothesize that circadian misalignment impacts cognition task-dependently. Using a biologically-driven paradigm mimicking night shift work, with a randomized, cross-over design, we show that misalignment between the circadian pacemaker and behavioral/environmental cycles increases cognitive vulnerability on sustained attention, cognitive throughput, information processing and visual-motor performance over multiple days, compared to circadian alignment (day shifts). Circadian misalignment effects are task-dependent: while they acutely impair sustained attention with recovery after 3-days, they progressively hinder daily learning. Individuals felt sleepier during circadian misalignment, but they did not rate their performance as worse. Furthermore, circadian misalignment effects on sustained attention depended on prior sleep history. Collectively, daily circadian misalignment may provide an important biological framework for developing countermeasures against adverse cognitive effects in shift workers.
format	article
author	Sarah L. Chellappa Christopher J. Morris Frank A. J. L. Scheer
author_facet	Sarah L. Chellappa Christopher J. Morris Frank A. J. L. Scheer
author_sort	Sarah L. Chellappa
title	Daily circadian misalignment impairs human cognitive performance task-dependently
title_short	Daily circadian misalignment impairs human cognitive performance task-dependently
title_full	Daily circadian misalignment impairs human cognitive performance task-dependently
title_fullStr	Daily circadian misalignment impairs human cognitive performance task-dependently
title_full_unstemmed	Daily circadian misalignment impairs human cognitive performance task-dependently
title_sort	daily circadian misalignment impairs human cognitive performance task-dependently
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c4942092090441c499646489cff8c7e0
work_keys_str_mv	AT sarahlchellappa dailycircadianmisalignmentimpairshumancognitiveperformancetaskdependently AT christopherjmorris dailycircadianmisalignmentimpairshumancognitiveperformancetaskdependently AT frankajlscheer dailycircadianmisalignmentimpairshumancognitiveperformancetaskdependently
_version_	1718387900836478976

Daily circadian misalignment impairs human cognitive performance task-dependently

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