Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreati...

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Auteurs principaux:	Xuexiang Han, Yiye Li, Ying Xu, Xiao Zhao, Yinlong Zhang, Xiao Yang, Yongwei Wang, Ruifang Zhao, Gregory J. Anderson, Yuliang Zhao, Guangjun Nie
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d
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id	oai:doaj.org-article:c495829fb81244ae9a98fa22e7548c0d
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spelling	oai:doaj.org-article:c495829fb81244ae9a98fa22e7548c0d2021-12-02T16:49:52ZReversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem10.1038/s41467-018-05906-x2041-1723https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05906-xhttps://doaj.org/toc/2041-1723Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.Xuexiang HanYiye LiYing XuXiao ZhaoYinlong ZhangXiao YangYongwei WangRuifang ZhaoGregory J. AndersonYuliang ZhaoGuangjun NieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xuexiang Han Yiye Li Ying Xu Xiao Zhao Yinlong Zhang Xiao Yang Yongwei Wang Ruifang Zhao Gregory J. Anderson Yuliang Zhao Guangjun Nie Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
description	Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.
format	article
author	Xuexiang Han Yiye Li Ying Xu Xiao Zhao Yinlong Zhang Xiao Yang Yongwei Wang Ruifang Zhao Gregory J. Anderson Yuliang Zhao Guangjun Nie
author_facet	Xuexiang Han Yiye Li Ying Xu Xiao Zhao Yinlong Zhang Xiao Yang Yongwei Wang Ruifang Zhao Gregory J. Anderson Yuliang Zhao Guangjun Nie
author_sort	Xuexiang Han
title	Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_short	Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_full	Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_fullStr	Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_full_unstemmed	Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_sort	reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d
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Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

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