Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreati...

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Autores principales: Xuexiang Han, Yiye Li, Ying Xu, Xiao Zhao, Yinlong Zhang, Xiao Yang, Yongwei Wang, Ruifang Zhao, Gregory J. Anderson, Yuliang Zhao, Guangjun Nie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d
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spelling oai:doaj.org-article:c495829fb81244ae9a98fa22e7548c0d2021-12-02T16:49:52ZReversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem10.1038/s41467-018-05906-x2041-1723https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05906-xhttps://doaj.org/toc/2041-1723Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.Xuexiang HanYiye LiYing XuXiao ZhaoYinlong ZhangXiao YangYongwei WangRuifang ZhaoGregory J. AndersonYuliang ZhaoGuangjun NieNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xuexiang Han
Yiye Li
Ying Xu
Xiao Zhao
Yinlong Zhang
Xiao Yang
Yongwei Wang
Ruifang Zhao
Gregory J. Anderson
Yuliang Zhao
Guangjun Nie
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
description Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreatic cancer treatment.
format article
author Xuexiang Han
Yiye Li
Ying Xu
Xiao Zhao
Yinlong Zhang
Xiao Yang
Yongwei Wang
Ruifang Zhao
Gregory J. Anderson
Yuliang Zhao
Guangjun Nie
author_facet Xuexiang Han
Yiye Li
Ying Xu
Xiao Zhao
Yinlong Zhang
Xiao Yang
Yongwei Wang
Ruifang Zhao
Gregory J. Anderson
Yuliang Zhao
Guangjun Nie
author_sort Xuexiang Han
title Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_short Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_full Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_fullStr Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_full_unstemmed Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
title_sort reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d
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