Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem

Stromal-tumour interactions play an important role in pancreatic cancer progression. Here, they describe the development of a tumour microenvironment-responsive gold nanoparticle system incorporating all-trans retinoic acid (ATRA) and siRNA against heat shock protein 47 (HSP47), for use in pancreati...

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Bibliographic Details
Main Authors: Xuexiang Han, Yiye Li, Ying Xu, Xiao Zhao, Yinlong Zhang, Xiao Yang, Yongwei Wang, Ruifang Zhao, Gregory J. Anderson, Yuliang Zhao, Guangjun Nie
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/c495829fb81244ae9a98fa22e7548c0d
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