Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests

Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model m...

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Autores principales:	Regev Schweiger, Eyal Fisher, Omer Weissbrod, Elior Rahmani, Martina Müller-Nurasyid, Sonja Kunze, Christian Gieger, Melanie Waldenberger, Saharon Rosset, Eran Halperin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c495cb7d4a6148b58cabe617686cac60
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spelling	oai:doaj.org-article:c495cb7d4a6148b58cabe617686cac602021-12-02T15:33:34ZDetecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests10.1038/s41467-018-07276-w2041-1723https://doaj.org/article/c495cb7d4a6148b58cabe617686cac602018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07276-whttps://doaj.org/toc/2041-1723Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model misspecification.Regev SchweigerEyal FisherOmer WeissbrodElior RahmaniMartina Müller-NurasyidSonja KunzeChristian GiegerMelanie WaldenbergerSaharon RossetEran HalperinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Regev Schweiger Eyal Fisher Omer Weissbrod Elior Rahmani Martina Müller-Nurasyid Sonja Kunze Christian Gieger Melanie Waldenberger Saharon Rosset Eran Halperin Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
description	Standard approaches for heritability and set testing in statistical genetics rely on parametric models that might not hold in reality and give inflated p-values. Here, the authors develop a fast method for permutation-based testing of marker sets and of heritability that does not suffer from model misspecification.
format	article
author	Regev Schweiger Eyal Fisher Omer Weissbrod Elior Rahmani Martina Müller-Nurasyid Sonja Kunze Christian Gieger Melanie Waldenberger Saharon Rosset Eran Halperin
author_facet	Regev Schweiger Eyal Fisher Omer Weissbrod Elior Rahmani Martina Müller-Nurasyid Sonja Kunze Christian Gieger Melanie Waldenberger Saharon Rosset Eran Halperin
author_sort	Regev Schweiger
title	Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
title_short	Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
title_full	Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
title_fullStr	Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
title_full_unstemmed	Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
title_sort	detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c495cb7d4a6148b58cabe617686cac60
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Detecting heritable phenotypes without a model using fast permutation testing for heritability and set-tests

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