Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy

Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferativ...

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Autores principales:	Sakamoto M, Hashimoto R, Yoshida I, Ubuka M, Maeno T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	neovascular glaucoma proliferative diabetic retinopathy vitrectomy Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c4984bd3fd644016a45cdd658850efc4
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spelling	oai:doaj.org-article:c4984bd3fd644016a45cdd658850efc42021-12-02T01:59:30ZRisk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy1177-5483https://doaj.org/article/c4984bd3fd644016a45cdd658850efc42018-11-01T00:00:00Zhttps://www.dovepress.com/risk-factors-for-neovascular-glaucoma-after-vitrectomy-in-eyes-with-pr-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Ocular parameters examined included preoperative best-corrected visual acuity, preoperative IOP, operative history (specifically panretinal photocoagulation), lens status, ocular pathology (eg, iris/angle neovascularization, tractional retinal detachment, diabetic macular edema, vitreous hemorrhage, combined tractional retinal detachment), intraoperative retinal tamponade use, vitrectomy gauge, combined lens extraction/vitrectomy procedure, subsequent surgical procedures, and pre- and postoperative intravitreal bevacizumab. Correlations between variables and postoperative NVG development were examined using logistic regression analyses (backward elimination method).Results: A total of 254 eyes of 196 consecutive subjects (146 men [74.5%], 54.0±10.8 years old) were included. Sixty of 254 eyes (23.6%) developed NVG. Several preoperative factors increased the risk of developing NVG, including iris/angle neovascularization (P=0.042), preoperative high IOP (P=0.005), low HbA1c (P=0.004), and administration of insulin (P=0.045). Intraoperative retinal tamponade also increased NVG risk (P=0.021, backward elimination method).Conclusion: Preoperative parameters such as elevated IOP, iris/angle neovascularization, fasting blood sugar and HbA1c discrepancies, administration of insulin, as well as use of retinal tamponade during retinal surgery were identified as the risk factors for developing NVG. Keywords: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy Sakamoto MHashimoto RYoshida IUbuka MMaeno TDove Medical Pressarticleneovascular glaucomaproliferative diabetic retinopathyvitrectomyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 2323-2329 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	neovascular glaucoma proliferative diabetic retinopathy vitrectomy Ophthalmology RE1-994
spellingShingle	neovascular glaucoma proliferative diabetic retinopathy vitrectomy Ophthalmology RE1-994 Sakamoto M Hashimoto R Yoshida I Ubuka M Maeno T Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
description	Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Makoto Ubuka, Takatoshi Maeno Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.Subjects and methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Ocular parameters examined included preoperative best-corrected visual acuity, preoperative IOP, operative history (specifically panretinal photocoagulation), lens status, ocular pathology (eg, iris/angle neovascularization, tractional retinal detachment, diabetic macular edema, vitreous hemorrhage, combined tractional retinal detachment), intraoperative retinal tamponade use, vitrectomy gauge, combined lens extraction/vitrectomy procedure, subsequent surgical procedures, and pre- and postoperative intravitreal bevacizumab. Correlations between variables and postoperative NVG development were examined using logistic regression analyses (backward elimination method).Results: A total of 254 eyes of 196 consecutive subjects (146 men [74.5%], 54.0±10.8 years old) were included. Sixty of 254 eyes (23.6%) developed NVG. Several preoperative factors increased the risk of developing NVG, including iris/angle neovascularization (P=0.042), preoperative high IOP (P=0.005), low HbA1c (P=0.004), and administration of insulin (P=0.045). Intraoperative retinal tamponade also increased NVG risk (P=0.021, backward elimination method).Conclusion: Preoperative parameters such as elevated IOP, iris/angle neovascularization, fasting blood sugar and HbA1c discrepancies, administration of insulin, as well as use of retinal tamponade during retinal surgery were identified as the risk factors for developing NVG. Keywords: neovascular glaucoma, proliferative diabetic retinopathy, vitrectomy
format	article
author	Sakamoto M Hashimoto R Yoshida I Ubuka M Maeno T
author_facet	Sakamoto M Hashimoto R Yoshida I Ubuka M Maeno T
author_sort	Sakamoto M
title	Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
title_short	Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
title_full	Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
title_fullStr	Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
title_full_unstemmed	Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
title_sort	risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c4984bd3fd644016a45cdd658850efc4
work_keys_str_mv	AT sakamotom riskfactorsforneovascularglaucomaaftervitrectomyineyeswithproliferativediabeticretinopathy AT hashimotor riskfactorsforneovascularglaucomaaftervitrectomyineyeswithproliferativediabeticretinopathy AT yoshidai riskfactorsforneovascularglaucomaaftervitrectomyineyeswithproliferativediabeticretinopathy AT ubukam riskfactorsforneovascularglaucomaaftervitrectomyineyeswithproliferativediabeticretinopathy AT maenot riskfactorsforneovascularglaucomaaftervitrectomyineyeswithproliferativediabeticretinopathy
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Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy

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