Orbital exenteration in immunodeficiency virus-infected patients

Kagmeni Giles,1,2 Yannick Bilong,1,2 Nomo Arlette,1,2 Nanfack Chantal,1,3 Bella Assumpta Lucienne1,3 1Eye Department, University of Yaoundé I, 2Yaounde Teaching Hospital, 3Gyneco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon Background: Orbital exenter...

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Autores principales:	Giles K, Bilong Y, Arlette N, Chantal N, Lucienne BA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Keywords: orbital tumors orbital exenteration squamous cell carcinoma HIV Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/c499c18c57934be1ad08c738af84b1aa
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spelling	oai:doaj.org-article:c499c18c57934be1ad08c738af84b1aa2021-12-02T00:15:20ZOrbital exenteration in immunodeficiency virus-infected patients1177-5483https://doaj.org/article/c499c18c57934be1ad08c738af84b1aa2016-10-01T00:00:00Zhttps://www.dovepress.com/orbital-exenteration-in-immunodeficiency-virus-infected-patients-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kagmeni Giles,1,2 Yannick Bilong,1,2 Nomo Arlette,1,2 Nanfack Chantal,1,3 Bella Assumpta Lucienne1,3 1Eye Department, University of Yaoundé I, 2Yaounde Teaching Hospital, 3Gyneco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon Background: Orbital exenteration (OE) is a disfiguring procedure most commonly performed for locally advanced and potentially life-threatening periorbital malignancies.Methods: We retrospectively reviewed records of 11 consecutive HIV patients who underwent OE for invasive orbital malignancy at our institution from January 2005 to December 2015. Patient demographic and clinic data and histopathology of the tumor were analyzed.Results: There were eight (72.72%) female and three (27.28%) male participants ranging in age from 31 to 52 years with an mean of 39.4 years. Nine patients had been known to be HIV-positive for at least 2 years, and HIV-positive status was revealed at presentation for two patients. The mean CD4 cell count was 154.4 cells/mm3. Histopathological examination showed invasive orbital squamous cell carcinomas in nine patients (81.81%), achromic orbital melanoma in one patient (9.09%), and adenoid cystic carcinoma in one patient (9.09%). None of the patients underwent primary orbital reconstruction. The mean follow-up time was 3.4 months. Only one patient who underwent adjuvant radiotherapy was seen after 12 months.Conclusion: Oculo-orbital malignancies are very aggressive in HIV-positive individuals, especially in untreated patients. Routine screening for suspected ocular surface lesions and early surgical removal of all these lesions could help to avoid the need to perform the radical and disfiguring OE procedure. Keywords: orbital tumors, achromic melanoma, squamous cell carcinoma, HIVGiles KBilong YArlette NChantal NLucienne BADove Medical PressarticleKeywords: orbital tumorsorbital exenterationsquamous cell carcinomaHIVOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 10, Pp 2055-2059 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Keywords: orbital tumors orbital exenteration squamous cell carcinoma HIV Ophthalmology RE1-994
spellingShingle	Keywords: orbital tumors orbital exenteration squamous cell carcinoma HIV Ophthalmology RE1-994 Giles K Bilong Y Arlette N Chantal N Lucienne BA Orbital exenteration in immunodeficiency virus-infected patients
description	Kagmeni Giles,1,2 Yannick Bilong,1,2 Nomo Arlette,1,2 Nanfack Chantal,1,3 Bella Assumpta Lucienne1,3 1Eye Department, University of Yaoundé I, 2Yaounde Teaching Hospital, 3Gyneco-Obstetric and Pediatric Hospital, Yaoundé, Cameroon Background: Orbital exenteration (OE) is a disfiguring procedure most commonly performed for locally advanced and potentially life-threatening periorbital malignancies.Methods: We retrospectively reviewed records of 11 consecutive HIV patients who underwent OE for invasive orbital malignancy at our institution from January 2005 to December 2015. Patient demographic and clinic data and histopathology of the tumor were analyzed.Results: There were eight (72.72%) female and three (27.28%) male participants ranging in age from 31 to 52 years with an mean of 39.4 years. Nine patients had been known to be HIV-positive for at least 2 years, and HIV-positive status was revealed at presentation for two patients. The mean CD4 cell count was 154.4 cells/mm3. Histopathological examination showed invasive orbital squamous cell carcinomas in nine patients (81.81%), achromic orbital melanoma in one patient (9.09%), and adenoid cystic carcinoma in one patient (9.09%). None of the patients underwent primary orbital reconstruction. The mean follow-up time was 3.4 months. Only one patient who underwent adjuvant radiotherapy was seen after 12 months.Conclusion: Oculo-orbital malignancies are very aggressive in HIV-positive individuals, especially in untreated patients. Routine screening for suspected ocular surface lesions and early surgical removal of all these lesions could help to avoid the need to perform the radical and disfiguring OE procedure. Keywords: orbital tumors, achromic melanoma, squamous cell carcinoma, HIV
format	article
author	Giles K Bilong Y Arlette N Chantal N Lucienne BA
author_facet	Giles K Bilong Y Arlette N Chantal N Lucienne BA
author_sort	Giles K
title	Orbital exenteration in immunodeficiency virus-infected patients
title_short	Orbital exenteration in immunodeficiency virus-infected patients
title_full	Orbital exenteration in immunodeficiency virus-infected patients
title_fullStr	Orbital exenteration in immunodeficiency virus-infected patients
title_full_unstemmed	Orbital exenteration in immunodeficiency virus-infected patients
title_sort	orbital exenteration in immunodeficiency virus-infected patients
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c499c18c57934be1ad08c738af84b1aa
work_keys_str_mv	AT gilesk orbitalexenterationinimmunodeficiencyvirusinfectedpatients AT bilongy orbitalexenterationinimmunodeficiencyvirusinfectedpatients AT arletten orbitalexenterationinimmunodeficiencyvirusinfectedpatients AT chantaln orbitalexenterationinimmunodeficiencyvirusinfectedpatients AT lucienneba orbitalexenterationinimmunodeficiencyvirusinfectedpatients
_version_	1718403889531715584

Orbital exenteration in immunodeficiency virus-infected patients

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