Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

Cluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is rel...

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Autores principales:	Małgorzata Kielar, Paulina Dumnicka, Ewa Ignacak, Alina Będkowska-Prokop, Agnieszka Gala-Błądzińska, Barbara Maziarz, Piotr Ceranowicz, Beata Kuśnierz-Cabala
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	kidney allograft glomerular filtration rate soluble cluster of differentiation 93 inflammation albuminuria Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c49bdaac300a484c8331faa403b86b61
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spelling	oai:doaj.org-article:c49bdaac300a484c8331faa403b86b612021-11-25T16:52:53ZSoluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients10.3390/biom111116232218-273Xhttps://doaj.org/article/c49bdaac300a484c8331faa403b86b612021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1623https://doaj.org/toc/2218-273XCluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is released to body fluids in inflammation. Data on sCD93 in kidney diseases are limited. Our aim was to evaluate serum sCD93 in long-term kidney transplant recipients as a marker of inflammation and endothelial dysfunction that may be potentially useful in early recognition of graft dysfunction. Seventy-eight adult patients with functioning kidney graft and stable clinical state were examined at least one year after kidney transplantation. Serum sCD93 was measured by enzyme immunosorbent assay. Estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria were assessed at baseline and over one-year follow-up. Increased sCD93 was associated with lower baseline eGFR independently of the confounders. Moreover, sCD93 was negatively associated with eGFR during one-year follow-up in simple analysis; however, this was not confirmed after adjustment for confounders. Baseline sCD93 was positively associated with baseline albuminuria and with increased proteinuria during the follow-up. Serum sCD93 was not correlated with other studied inflammatory markers (interleukin 6, C-reactive protein, procalcitonin and C3 and C4 complement components). To the best of our knowledge, this is the first report regarding the concentrations of sCD93 in kidney transplant recipients and one of the first reports showing the inverse association between sCD93 and renal function. Serum sCD93 should be further evaluated as a diagnostic and prognostic marker in renal transplantation.Małgorzata KielarPaulina DumnickaEwa IgnacakAlina Będkowska-ProkopAgnieszka Gala-BłądzińskaBarbara MaziarzPiotr CeranowiczBeata Kuśnierz-CabalaMDPI AGarticlekidney allograftglomerular filtration ratesoluble cluster of differentiation 93inflammationalbuminuriaMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1623, p 1623 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	kidney allograft glomerular filtration rate soluble cluster of differentiation 93 inflammation albuminuria Microbiology QR1-502
spellingShingle	kidney allograft glomerular filtration rate soluble cluster of differentiation 93 inflammation albuminuria Microbiology QR1-502 Małgorzata Kielar Paulina Dumnicka Ewa Ignacak Alina Będkowska-Prokop Agnieszka Gala-Błądzińska Barbara Maziarz Piotr Ceranowicz Beata Kuśnierz-Cabala Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
description	Cluster of differentiation 93 (CD93), also known as complement component 1q receptor 1 is a transmembrane glycoprotein expressed in endothelial and hematopoietic cells and associated with phagocytosis, cell adhesion, angiogenesis and inflammation. The extracellular part, soluble CD93 (sCD93), is released to body fluids in inflammation. Data on sCD93 in kidney diseases are limited. Our aim was to evaluate serum sCD93 in long-term kidney transplant recipients as a marker of inflammation and endothelial dysfunction that may be potentially useful in early recognition of graft dysfunction. Seventy-eight adult patients with functioning kidney graft and stable clinical state were examined at least one year after kidney transplantation. Serum sCD93 was measured by enzyme immunosorbent assay. Estimated glomerular filtration rate (eGFR) and albuminuria or proteinuria were assessed at baseline and over one-year follow-up. Increased sCD93 was associated with lower baseline eGFR independently of the confounders. Moreover, sCD93 was negatively associated with eGFR during one-year follow-up in simple analysis; however, this was not confirmed after adjustment for confounders. Baseline sCD93 was positively associated with baseline albuminuria and with increased proteinuria during the follow-up. Serum sCD93 was not correlated with other studied inflammatory markers (interleukin 6, C-reactive protein, procalcitonin and C3 and C4 complement components). To the best of our knowledge, this is the first report regarding the concentrations of sCD93 in kidney transplant recipients and one of the first reports showing the inverse association between sCD93 and renal function. Serum sCD93 should be further evaluated as a diagnostic and prognostic marker in renal transplantation.
format	article
author	Małgorzata Kielar Paulina Dumnicka Ewa Ignacak Alina Będkowska-Prokop Agnieszka Gala-Błądzińska Barbara Maziarz Piotr Ceranowicz Beata Kuśnierz-Cabala
author_facet	Małgorzata Kielar Paulina Dumnicka Ewa Ignacak Alina Będkowska-Prokop Agnieszka Gala-Błądzińska Barbara Maziarz Piotr Ceranowicz Beata Kuśnierz-Cabala
author_sort	Małgorzata Kielar
title	Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
title_short	Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
title_full	Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
title_fullStr	Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
title_full_unstemmed	Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients
title_sort	soluble complement component 1q receptor 1 (scd93) is associated with graft function in kidney transplant recipients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c49bdaac300a484c8331faa403b86b61
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Soluble Complement Component 1q Receptor 1 (sCD93) Is Associated with Graft Function in Kidney Transplant Recipients

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