Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR

Tudor interacting repair regulator (TIRR) is a negative regulator of 53BP1 in DNA damage repair processes. Here the authors give mechanistic insights into how TIRR mediates suppression by solving the crystal structure of TIRR bound to the 53BP1 tandem Tudor domain (TTD).

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Autores principales:	Jiaxu Wang, Zenglin Yuan, Yaqi Cui, Rong Xie, Guang Yang, Muzaffer A. Kassab, Mengxi Wang, Yinliang Ma, Chen Wu, Xiaochun Yu, Xiuhua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c49f7c9d4afb46d58974291e19e39bff
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spelling	oai:doaj.org-article:c49f7c9d4afb46d58974291e19e39bff2021-12-02T16:49:37ZMolecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR10.1038/s41467-018-05174-92041-1723https://doaj.org/article/c49f7c9d4afb46d58974291e19e39bff2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05174-9https://doaj.org/toc/2041-1723Tudor interacting repair regulator (TIRR) is a negative regulator of 53BP1 in DNA damage repair processes. Here the authors give mechanistic insights into how TIRR mediates suppression by solving the crystal structure of TIRR bound to the 53BP1 tandem Tudor domain (TTD).Jiaxu WangZenglin YuanYaqi CuiRong XieGuang YangMuzaffer A. KassabMengxi WangYinliang MaChen WuXiaochun YuXiuhua LiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiaxu Wang Zenglin Yuan Yaqi Cui Rong Xie Guang Yang Muzaffer A. Kassab Mengxi Wang Yinliang Ma Chen Wu Xiaochun Yu Xiuhua Liu Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
description	Tudor interacting repair regulator (TIRR) is a negative regulator of 53BP1 in DNA damage repair processes. Here the authors give mechanistic insights into how TIRR mediates suppression by solving the crystal structure of TIRR bound to the 53BP1 tandem Tudor domain (TTD).
format	article
author	Jiaxu Wang Zenglin Yuan Yaqi Cui Rong Xie Guang Yang Muzaffer A. Kassab Mengxi Wang Yinliang Ma Chen Wu Xiaochun Yu Xiuhua Liu
author_facet	Jiaxu Wang Zenglin Yuan Yaqi Cui Rong Xie Guang Yang Muzaffer A. Kassab Mengxi Wang Yinliang Ma Chen Wu Xiaochun Yu Xiuhua Liu
author_sort	Jiaxu Wang
title	Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
title_short	Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
title_full	Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
title_fullStr	Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
title_full_unstemmed	Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
title_sort	molecular basis for the inhibition of the methyl-lysine binding function of 53bp1 by tirr
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c49f7c9d4afb46d58974291e19e39bff
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Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR

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