Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy

Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic–ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared th...

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Autores principales:	Da-Yang Chen, Inn-Chi Lee, Xing-An Wang, Swee-Hee Wong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	newborn HIE biomarker hearing impairment neurodevelopment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c4a585bb73694d12a7b9a23080d358d5
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spelling	oai:doaj.org-article:c4a585bb73694d12a7b9a23080d358d52021-11-25T17:21:14ZEarly Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy10.3390/diagnostics111120562075-4418https://doaj.org/article/c4a585bb73694d12a7b9a23080d358d52021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2056https://doaj.org/toc/2075-4418Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic–ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87%; <i>p</i> < 0.001). More patients with moderate-to-severe HIE had confirmed HIs (<i>p</i> = 0.020; odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 ± 51.0 vs. 71.4 ± 48.4; U = 181, <i>p</i> = 0.032) and serum glucose (159.5 ± 86.1 vs. 112.1 ± 62.3; U = 166, <i>p</i> = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10%; <i>p</i> = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE.Da-Yang ChenInn-Chi LeeXing-An WangSwee-Hee WongMDPI AGarticlenewbornHIEbiomarkerhearing impairmentneurodevelopmentMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2056, p 2056 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	newborn HIE biomarker hearing impairment neurodevelopment Medicine (General) R5-920
spellingShingle	newborn HIE biomarker hearing impairment neurodevelopment Medicine (General) R5-920 Da-Yang Chen Inn-Chi Lee Xing-An Wang Swee-Hee Wong Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
description	Identifying biomarkers for hearing impairments (HIs) in patients with neonatal hypoxic–ischemic encephalopathy (HIE), to initialize early hearing habilitation, is crucial. Seventy-eight neonates with HIE were divided into the following two groups: those with HIs and those without HIs. We compared those patients with 11,837 newborns without HIE, and analyzed the risk factors of HIs among neonatal HIE. Of the 78 patients, 11 were confirmed to have an HI, which is a substantially higher percentage than in the 11,837 newborns without HIE (14.1% vs. 0.87%; <i>p</i> < 0.001). More patients with moderate-to-severe HIE had confirmed HIs (<i>p</i> = 0.020; odds ratio, 8.61) than those with mild HIE. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE. The patients who exhibited HIs had significantly higher lactate (104.8 ± 51.0 vs. 71.4 ± 48.4; U = 181, <i>p</i> = 0.032) and serum glucose (159.5 ± 86.1 vs. 112.1 ± 62.3; U = 166, <i>p</i> = 0.036) levels than those without HIs. A higher prevalence of HIs was noted in the patients with stage III HIE than those with stage II HIE (43.8% vs. 10%; <i>p</i> = 0.008). The degree of HI correlated with brain anomalies and neurodevelopmental outcomes at 1 year of age. Clinical staging, and blood lactate and glucose levels could be predictive factors for HIs among patients with HIE.
format	article
author	Da-Yang Chen Inn-Chi Lee Xing-An Wang Swee-Hee Wong
author_facet	Da-Yang Chen Inn-Chi Lee Xing-An Wang Swee-Hee Wong
author_sort	Da-Yang Chen
title	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
title_short	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
title_full	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
title_fullStr	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
title_full_unstemmed	Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy
title_sort	early biomarkers and hearing impairments in patients with neonatal hypoxic–ischemic encephalopathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c4a585bb73694d12a7b9a23080d358d5
work_keys_str_mv	AT dayangchen earlybiomarkersandhearingimpairmentsinpatientswithneonatalhypoxicischemicencephalopathy AT innchilee earlybiomarkersandhearingimpairmentsinpatientswithneonatalhypoxicischemicencephalopathy AT xinganwang earlybiomarkersandhearingimpairmentsinpatientswithneonatalhypoxicischemicencephalopathy AT sweeheewong earlybiomarkersandhearingimpairmentsinpatientswithneonatalhypoxicischemicencephalopathy
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Early Biomarkers and Hearing Impairments in Patients with Neonatal Hypoxic–Ischemic Encephalopathy

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