Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

Abstract Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed...

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Autores principales:	Kristina S. Fluitman, Tim J. van den Broek, Max Nieuwdorp, Marjolein Visser, Richard G. IJzerman, Bart J. F. Keijser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4a6d602049f444fa5ca99b8254d89a9
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spelling	oai:doaj.org-article:c4a6d602049f444fa5ca99b8254d89a92021-12-05T12:12:18ZAssociations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults10.1038/s41598-021-02558-82045-2322https://doaj.org/article/c4a6d602049f444fa5ca99b8254d89a92021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02558-8https://doaj.org/toc/2045-2322Abstract Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.Kristina S. FluitmanTim J. van den BroekMax NieuwdorpMarjolein VisserRichard G. IJzermanBart J. F. KeijserNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kristina S. Fluitman Tim J. van den Broek Max Nieuwdorp Marjolein Visser Richard G. IJzerman Bart J. F. Keijser Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
description	Abstract Poor taste and smell function are widely thought to contribute to the development of poor appetite and undernutrition in older adults. It has been hypothesized that the oral microbiota play a role as well, but evidence is scarce. In a cross-sectional cohort of 356 older adults, we performed taste and smell tests, collected anthropometric measurements and tongue swabs for analysis of microbial composition (16S rRNA sequencing) and Candida albicans abundance (qPCR). Older age, edentation, poor smell and poor appetite were associated with lower alpha diversity and explained a significant amount of beta diversity. Moreover, a lower Streptococcus salivarius abundance was associated with poor smell identification score, whereas high C. albicans abundance seemed to be associated with poor smell discrimination score. In our population, neither the tongue microbiota, nor C. albicans were associated with poor taste or directly with undernutrition. Our findings do suggest a host-microbe interaction with regard to smell perception and appetite.
format	article
author	Kristina S. Fluitman Tim J. van den Broek Max Nieuwdorp Marjolein Visser Richard G. IJzerman Bart J. F. Keijser
author_facet	Kristina S. Fluitman Tim J. van den Broek Max Nieuwdorp Marjolein Visser Richard G. IJzerman Bart J. F. Keijser
author_sort	Kristina S. Fluitman
title	Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
title_short	Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
title_full	Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
title_fullStr	Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
title_full_unstemmed	Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults
title_sort	associations of the oral microbiota and candida with taste, smell, appetite and undernutrition in older adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4a6d602049f444fa5ca99b8254d89a9
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Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults

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