Risk factors and incidence of third trimester stillbirths in China

Abstract About 2.6 million third-trimester stillbirths occur annually worldwide, mostly in low- and middle-income countries. However, the causes of stillbirths are rarely investigated. We performed a retrospective, hospital-based study in Zhejiang Province, southern China, of the causes of third-tri...

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Autores principales:	Ying Hu, Qi Wu, Jia Liu, Die Hong, Yuqing Zou, Jingjing Lu, Yuhui Wang, Danqing Chen, Lu Qi, Zhaoxia Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4a989b8491c4d4fa4ec2024342fc558
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spelling	oai:doaj.org-article:c4a989b8491c4d4fa4ec2024342fc5582021-12-02T17:24:22ZRisk factors and incidence of third trimester stillbirths in China10.1038/s41598-021-92106-12045-2322https://doaj.org/article/c4a989b8491c4d4fa4ec2024342fc5582021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92106-1https://doaj.org/toc/2045-2322Abstract About 2.6 million third-trimester stillbirths occur annually worldwide, mostly in low- and middle-income countries. However, the causes of stillbirths are rarely investigated. We performed a retrospective, hospital-based study in Zhejiang Province, southern China, of the causes of third-trimester stillbirths. Causes of stillbirths were classified using the Relevant Condition at Death classification system. From January 1, 2013, to December 31, 2018, we enrolled 341 stillbirths (born to 338 women) from 111,275 perinatal fetuses (born to 107,142 women), as well as 293 control cases (born to 291 women). The total incidence of third-trimester stillbirths was 3.06/1000 (341/111,275). There were higher proportions of women with a high body mass index, twins, pregnancy-induced hypertension, assisted reproduction and other risk factors among the antepartum than the control cases. The antepartum stillbirth fetuses were of lower median birth weight and gestational age and had a smaller portion of translucent amniotic fluid than the control cases. The antepartum stillbirth fetuses had a higher frequency of abnormalities detected prenatally and of fetal growth restriction than the control cases. Of 341 cases (born to 338 mothers), the most common causes of stillbirth were fetal conditions [117 (34.3%) cases], umbilical cord [88 (25.8%)], maternal conditions [34 (10.0%)], placental conditions [31 (9.1%)], and intrapartum [28 (8.2%)]. Only eight (2.3%), three (0.9%), and two (0.6%) stillbirths were attributed to amniotic fluid, trauma, and uterus, respectively. In 30 (8.8%) cases, the cause of death was unclassified. In conclusion, targeted investigation can ascertain the causes of most cases of third-trimester stillbirths.Ying HuQi WuJia LiuDie HongYuqing ZouJingjing LuYuhui WangDanqing ChenLu QiZhaoxia LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ying Hu Qi Wu Jia Liu Die Hong Yuqing Zou Jingjing Lu Yuhui Wang Danqing Chen Lu Qi Zhaoxia Liang Risk factors and incidence of third trimester stillbirths in China
description	Abstract About 2.6 million third-trimester stillbirths occur annually worldwide, mostly in low- and middle-income countries. However, the causes of stillbirths are rarely investigated. We performed a retrospective, hospital-based study in Zhejiang Province, southern China, of the causes of third-trimester stillbirths. Causes of stillbirths were classified using the Relevant Condition at Death classification system. From January 1, 2013, to December 31, 2018, we enrolled 341 stillbirths (born to 338 women) from 111,275 perinatal fetuses (born to 107,142 women), as well as 293 control cases (born to 291 women). The total incidence of third-trimester stillbirths was 3.06/1000 (341/111,275). There were higher proportions of women with a high body mass index, twins, pregnancy-induced hypertension, assisted reproduction and other risk factors among the antepartum than the control cases. The antepartum stillbirth fetuses were of lower median birth weight and gestational age and had a smaller portion of translucent amniotic fluid than the control cases. The antepartum stillbirth fetuses had a higher frequency of abnormalities detected prenatally and of fetal growth restriction than the control cases. Of 341 cases (born to 338 mothers), the most common causes of stillbirth were fetal conditions [117 (34.3%) cases], umbilical cord [88 (25.8%)], maternal conditions [34 (10.0%)], placental conditions [31 (9.1%)], and intrapartum [28 (8.2%)]. Only eight (2.3%), three (0.9%), and two (0.6%) stillbirths were attributed to amniotic fluid, trauma, and uterus, respectively. In 30 (8.8%) cases, the cause of death was unclassified. In conclusion, targeted investigation can ascertain the causes of most cases of third-trimester stillbirths.
format	article
author	Ying Hu Qi Wu Jia Liu Die Hong Yuqing Zou Jingjing Lu Yuhui Wang Danqing Chen Lu Qi Zhaoxia Liang
author_facet	Ying Hu Qi Wu Jia Liu Die Hong Yuqing Zou Jingjing Lu Yuhui Wang Danqing Chen Lu Qi Zhaoxia Liang
author_sort	Ying Hu
title	Risk factors and incidence of third trimester stillbirths in China
title_short	Risk factors and incidence of third trimester stillbirths in China
title_full	Risk factors and incidence of third trimester stillbirths in China
title_fullStr	Risk factors and incidence of third trimester stillbirths in China
title_full_unstemmed	Risk factors and incidence of third trimester stillbirths in China
title_sort	risk factors and incidence of third trimester stillbirths in china
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4a989b8491c4d4fa4ec2024342fc558
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Risk factors and incidence of third trimester stillbirths in China

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