Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

Humans are less sensitive to the therapeutic effects of botulinum neurotoxin B (BoNT/B) than the animal models it is tested on due to differences between the human and the mouse receptors. Here, the authors engineer BoNT/B to improve its affinity to human receptors and enhance its therapeutic effica...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Tao, Lisheng Peng, Ronnie P.-A. Berntsson, Sai Man Liu, SunHyun Park, Feifan Yu, Christopher Boone, Shilpa Palan, Matthew Beard, Pierre-Etienne Chabrier, Pål Stenmark, Johannes Krupp, Min Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4a98be4d71a49939f118b13ff4c9b03
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c4a98be4d71a49939f118b13ff4c9b03
record_format	dspace
spelling	oai:doaj.org-article:c4a98be4d71a49939f118b13ff4c9b032021-12-02T13:27:30ZEngineered botulinum neurotoxin B with improved efficacy for targeting human receptors10.1038/s41467-017-00064-y2041-1723https://doaj.org/article/c4a98be4d71a49939f118b13ff4c9b032017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00064-yhttps://doaj.org/toc/2041-1723Humans are less sensitive to the therapeutic effects of botulinum neurotoxin B (BoNT/B) than the animal models it is tested on due to differences between the human and the mouse receptors. Here, the authors engineer BoNT/B to improve its affinity to human receptors and enhance its therapeutic efficacy.Liang TaoLisheng PengRonnie P.-A. BerntssonSai Man LiuSunHyun ParkFeifan YuChristopher BooneShilpa PalanMatthew BeardPierre-Etienne ChabrierPål StenmarkJohannes KruppMin DongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Liang Tao Lisheng Peng Ronnie P.-A. Berntsson Sai Man Liu SunHyun Park Feifan Yu Christopher Boone Shilpa Palan Matthew Beard Pierre-Etienne Chabrier Pål Stenmark Johannes Krupp Min Dong Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
description	Humans are less sensitive to the therapeutic effects of botulinum neurotoxin B (BoNT/B) than the animal models it is tested on due to differences between the human and the mouse receptors. Here, the authors engineer BoNT/B to improve its affinity to human receptors and enhance its therapeutic efficacy.
format	article
author	Liang Tao Lisheng Peng Ronnie P.-A. Berntsson Sai Man Liu SunHyun Park Feifan Yu Christopher Boone Shilpa Palan Matthew Beard Pierre-Etienne Chabrier Pål Stenmark Johannes Krupp Min Dong
author_facet	Liang Tao Lisheng Peng Ronnie P.-A. Berntsson Sai Man Liu SunHyun Park Feifan Yu Christopher Boone Shilpa Palan Matthew Beard Pierre-Etienne Chabrier Pål Stenmark Johannes Krupp Min Dong
author_sort	Liang Tao
title	Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
title_short	Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
title_full	Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
title_fullStr	Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
title_full_unstemmed	Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
title_sort	engineered botulinum neurotoxin b with improved efficacy for targeting human receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c4a98be4d71a49939f118b13ff4c9b03
work_keys_str_mv	AT liangtao engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT lishengpeng engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT ronniepaberntsson engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT saimanliu engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT sunhyunpark engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT feifanyu engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT christopherboone engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT shilpapalan engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT matthewbeard engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT pierreetiennechabrier engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT palstenmark engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT johanneskrupp engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors AT mindong engineeredbotulinumneurotoxinbwithimprovedefficacyfortargetinghumanreceptors
_version_	1718393000623603712

Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors

Ejemplares similares