Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

Abstract Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffus...

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Autores principales:	Nagesh Adluru, Zhan Luo, Carol A. Van Hulle, Andrew J. Schoen, Richard J. Davidson, Andrew L. Alexander, H. Hill Goldsmith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4aa347be64c4149a99d02b5b9a3308a
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spelling	oai:doaj.org-article:c4aa347be64c4149a99d02b5b9a3308a2021-12-02T12:31:48ZAnxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach10.1038/s41598-017-08107-62045-2322https://doaj.org/article/c4aa347be64c4149a99d02b5b9a3308a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08107-6https://doaj.org/toc/2045-2322Abstract Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs. Twins aged 13–18 years reported on symptoms of generalized anxiety and social phobia prior to participating in a neuroimaging visit. Regions of interest from the JHU ICBM atlas, including uncinate fasciculus and sagittal stratum as a control tract, were registered to the study template. We incorporated multiple diffusion tensor measures to characterize the white matter differences. Within twin pairs, the more anxious twin exhibited decreased fractional anisotropy (t = −2.22, p = 0.032) and axial diffusivity (t = −2.38, p = 0.022) in the left UF compared to the less anxious twin, controlling for age and gender. This study demonstrated the feasibility and advantages of adopting the MZ twin design for DTI measures in neuroimaging research.Nagesh AdluruZhan LuoCarol A. Van HulleAndrew J. SchoenRichard J. DavidsonAndrew L. AlexanderH. Hill GoldsmithNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nagesh Adluru Zhan Luo Carol A. Van Hulle Andrew J. Schoen Richard J. Davidson Andrew L. Alexander H. Hill Goldsmith Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
description	Abstract Anxiety is linked to deficits in structural and functional connectivity between limbic structures and pre-frontal cortices. We employed a monozygotic (MZ) twin difference design to examine the relationship between structural characteristics of the uncinate fasciculus (UF) measured by Diffusion Tensor Imaging (DTI) and anxiety symptoms in a sample of N = 100 monozygotic (genetically identical), adolescent twins. The MZ difference design allowed us focus on environmental factors that vary within twin pairs while controlling for genetic and environmental factors shared by twin pairs. Twins aged 13–18 years reported on symptoms of generalized anxiety and social phobia prior to participating in a neuroimaging visit. Regions of interest from the JHU ICBM atlas, including uncinate fasciculus and sagittal stratum as a control tract, were registered to the study template. We incorporated multiple diffusion tensor measures to characterize the white matter differences. Within twin pairs, the more anxious twin exhibited decreased fractional anisotropy (t = −2.22, p = 0.032) and axial diffusivity (t = −2.38, p = 0.022) in the left UF compared to the less anxious twin, controlling for age and gender. This study demonstrated the feasibility and advantages of adopting the MZ twin design for DTI measures in neuroimaging research.
format	article
author	Nagesh Adluru Zhan Luo Carol A. Van Hulle Andrew J. Schoen Richard J. Davidson Andrew L. Alexander H. Hill Goldsmith
author_facet	Nagesh Adluru Zhan Luo Carol A. Van Hulle Andrew J. Schoen Richard J. Davidson Andrew L. Alexander H. Hill Goldsmith
author_sort	Nagesh Adluru
title	Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
title_short	Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
title_full	Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
title_fullStr	Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
title_full_unstemmed	Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach
title_sort	anxiety-related experience-dependent white matter structural differences in adolescence: a monozygotic twin difference approach
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c4aa347be64c4149a99d02b5b9a3308a
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Anxiety-related experience-dependent white matter structural differences in adolescence: A monozygotic twin difference approach

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