The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis

Lifeng Zhao,1 Xuesong Li,2 Guanying Liu,1 Baoling Han,1 Jian Wang,1 Xia Jiang1 1Department of Endocrinology, Tianjin First Center Hospital, Tianjin, China; 2First Center Clinical Medical Institute, Tianjin Medical University, Tianjin, China Objective: Recent controversial evidence suggests that ma...

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Autores principales:	Zhao L, Li X, Liu G, Han B, Wang J, Jiang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	maternal diabetes attention deficit hyperactivity disorder meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c4ac89f360e248d881a85af4ab2e8b7c
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spelling	oai:doaj.org-article:c4ac89f360e248d881a85af4ab2e8b7c2021-12-02T04:55:49ZThe association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis1178-2021https://doaj.org/article/c4ac89f360e248d881a85af4ab2e8b7c2019-03-01T00:00:00Zhttps://www.dovepress.com/the-association-of-maternal-diabetes-with-attention-deficit-and-hypera-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lifeng Zhao,1 Xuesong Li,2 Guanying Liu,1 Baoling Han,1 Jian Wang,1 Xia Jiang1 1Department of Endocrinology, Tianjin First Center Hospital, Tianjin, China; 2First Center Clinical Medical Institute, Tianjin Medical University, Tianjin, China Objective: Recent controversial evidence suggests that maternal diabetes may increase the risk of attention deficit and hyperactivity disorder (ADHD) in offspring. To examine this potential association, a systematic literature search and meta-analysis was performed. Methods: OR or risk ratio (RR) from each study was obtained and combined for evaluating the risk. Six cohort studies and three case-control studies were included in the present study. Results: The meta-analysis of the highly heterogeneous case-control studies did not find significant association between maternal diabetes and ADHD risk (OR: 1.20, 95% CI: 0.96–1.49). The combining of the cohort studies demonstrated that offspring of diabetic mothers were at higher risk of ADHD (RR: 1.40, 95% CI: 1.27–1.54); however, publication bias was identified. When exposure was specified as gestational diabetes mellitus (GDM), GDM exposure increased the risk of ADHD for children by 164% (95% CI: 1.25–5.56) in a Caucasian population. Neither heterogeneity nor publication bias was detected. Conclusion: Maternal diabetes, especially GDM, is probably a risk factor for ADHD in the Caucasian population. More studies based on large sample size and different ethnicities are needed to confirm this association. Keywords: maternal diabetes, attention deficit hyperactivity disorder, meta-analysisZhao LLi XLiu GHan BWang JJiang XDove Medical Pressarticlematernal diabetesattention deficit hyperactivity disordermeta-analysisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 675-684 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	maternal diabetes attention deficit hyperactivity disorder meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	maternal diabetes attention deficit hyperactivity disorder meta-analysis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhao L Li X Liu G Han B Wang J Jiang X The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
description	Lifeng Zhao,1 Xuesong Li,2 Guanying Liu,1 Baoling Han,1 Jian Wang,1 Xia Jiang1 1Department of Endocrinology, Tianjin First Center Hospital, Tianjin, China; 2First Center Clinical Medical Institute, Tianjin Medical University, Tianjin, China Objective: Recent controversial evidence suggests that maternal diabetes may increase the risk of attention deficit and hyperactivity disorder (ADHD) in offspring. To examine this potential association, a systematic literature search and meta-analysis was performed. Methods: OR or risk ratio (RR) from each study was obtained and combined for evaluating the risk. Six cohort studies and three case-control studies were included in the present study. Results: The meta-analysis of the highly heterogeneous case-control studies did not find significant association between maternal diabetes and ADHD risk (OR: 1.20, 95% CI: 0.96–1.49). The combining of the cohort studies demonstrated that offspring of diabetic mothers were at higher risk of ADHD (RR: 1.40, 95% CI: 1.27–1.54); however, publication bias was identified. When exposure was specified as gestational diabetes mellitus (GDM), GDM exposure increased the risk of ADHD for children by 164% (95% CI: 1.25–5.56) in a Caucasian population. Neither heterogeneity nor publication bias was detected. Conclusion: Maternal diabetes, especially GDM, is probably a risk factor for ADHD in the Caucasian population. More studies based on large sample size and different ethnicities are needed to confirm this association. Keywords: maternal diabetes, attention deficit hyperactivity disorder, meta-analysis
format	article
author	Zhao L Li X Liu G Han B Wang J Jiang X
author_facet	Zhao L Li X Liu G Han B Wang J Jiang X
author_sort	Zhao L
title	The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
title_short	The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
title_full	The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
title_fullStr	The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
title_full_unstemmed	The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
title_sort	association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/c4ac89f360e248d881a85af4ab2e8b7c
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The association of maternal diabetes with attention deficit and hyperactivity disorder in offspring: a meta-analysis

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