A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells

Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown imp...

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Autores principales:	Torben Knuschke, Sebastian Kollenda, Christina Wenzek, Gennadiy Zelinskyy, Philine Steinbach, Ulf Dittmer, Jan Buer, Matthias Epple, Astrid M. Westendorf
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c4b0311ffd9843a69b3db45c416f2a05
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spelling	oai:doaj.org-article:c4b0311ffd9843a69b3db45c416f2a052021-11-03T18:15:37ZA Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells2161-21292150-751110.1128/mBio.02121-20https://doaj.org/article/c4b0311ffd9843a69b3db45c416f2a052021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02121-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown impressive results against solid tumors.Torben KnuschkeSebastian KollendaChristina WenzekGennadiy ZelinskyyPhiline SteinbachUlf DittmerJan BuerMatthias EppleAstrid M. WestendorfAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Torben Knuschke Sebastian Kollenda Christina Wenzek Gennadiy Zelinskyy Philine Steinbach Ulf Dittmer Jan Buer Matthias Epple Astrid M. Westendorf A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
description	Despite significant efforts, vaccines are not yet available for every infectious pathogen, and the search for a protective approach to prevent the establishment of chronic infections, i.e., with HIV, continues. Immune checkpoint therapies targeting inhibitory receptors, such as PD-1, have shown impressive results against solid tumors.
format	article
author	Torben Knuschke Sebastian Kollenda Christina Wenzek Gennadiy Zelinskyy Philine Steinbach Ulf Dittmer Jan Buer Matthias Epple Astrid M. Westendorf
author_facet	Torben Knuschke Sebastian Kollenda Christina Wenzek Gennadiy Zelinskyy Philine Steinbach Ulf Dittmer Jan Buer Matthias Epple Astrid M. Westendorf
author_sort	Torben Knuschke
title	A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
title_short	A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
title_full	A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
title_fullStr	A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
title_full_unstemmed	A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells
title_sort	combination of anti-pd-l1 treatment and therapeutic vaccination facilitates improved retroviral clearance via reactivation of highly exhausted t cells
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/c4b0311ffd9843a69b3db45c416f2a05
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A Combination of Anti-PD-L1 Treatment and Therapeutic Vaccination Facilitates Improved Retroviral Clearance via Reactivation of Highly Exhausted T Cells

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