PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome

The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.

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Autores principales:	Deepti Sharma, Louis De Falco, Sivaraman Padavattan, Chang Rao, Susana Geifman-Shochat, Chuan-Fa Liu, Curt A. Davey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c4b2c946501c463c9cc98da888f89daf
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spelling	oai:doaj.org-article:c4b2c946501c463c9cc98da888f89daf2021-12-02T14:40:01ZPARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome10.1038/s41467-019-13641-02041-1723https://doaj.org/article/c4b2c946501c463c9cc98da888f89daf2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13641-0https://doaj.org/toc/2041-1723The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.Deepti SharmaLouis De FalcoSivaraman PadavattanChang RaoSusana Geifman-ShochatChuan-Fa LiuCurt A. DaveyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepti Sharma Louis De Falco Sivaraman Padavattan Chang Rao Susana Geifman-Shochat Chuan-Fa Liu Curt A. Davey PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
description	The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.
format	article
author	Deepti Sharma Louis De Falco Sivaraman Padavattan Chang Rao Susana Geifman-Shochat Chuan-Fa Liu Curt A. Davey
author_facet	Deepti Sharma Louis De Falco Sivaraman Padavattan Chang Rao Susana Geifman-Shochat Chuan-Fa Liu Curt A. Davey
author_sort	Deepti Sharma
title	PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
title_short	PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
title_full	PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
title_fullStr	PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
title_full_unstemmed	PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
title_sort	parp1 exhibits enhanced association and catalytic efficiency with γh2a.x-nucleosome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c4b2c946501c463c9cc98da888f89daf
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PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome

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