The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo

Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to treat RAS-driven tumours.

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Autores principales:	Briana Rackley, Chang-Soo Seong, Evan Kiely, Rebecca E. Parker, Manali Rupji, Bhakti Dwivedi, John M. Heddleston, William Giang, Neil Anthony, Teng-Leong Chew, Melissa Gilbert-Ross
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
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spelling	oai:doaj.org-article:c4b905d7cae645a3acc0a94273ef360d2021-12-02T14:16:06ZThe level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo10.1038/s42003-021-01663-82399-3642https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01663-8https://doaj.org/toc/2399-3642Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to treat RAS-driven tumours.Briana RackleyChang-Soo SeongEvan KielyRebecca E. ParkerManali RupjiBhakti DwivediJohn M. HeddlestonWilliam GiangNeil AnthonyTeng-Leong ChewMelissa Gilbert-RossNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Briana Rackley Chang-Soo Seong Evan Kiely Rebecca E. Parker Manali Rupji Bhakti Dwivedi John M. Heddleston William Giang Neil Anthony Teng-Leong Chew Melissa Gilbert-Ross The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
description	Rackley, Seong et al use a Drosophila model of Ras/Lkb1 mutant carcinoma to show that high levels of the KRAS oncogene drive the malignant transformation of LKB1 mutant tissue. This pathway could be used as a target for future therapies that aim to treat RAS-driven tumours.
format	article
author	Briana Rackley Chang-Soo Seong Evan Kiely Rebecca E. Parker Manali Rupji Bhakti Dwivedi John M. Heddleston William Giang Neil Anthony Teng-Leong Chew Melissa Gilbert-Ross
author_facet	Briana Rackley Chang-Soo Seong Evan Kiely Rebecca E. Parker Manali Rupji Bhakti Dwivedi John M. Heddleston William Giang Neil Anthony Teng-Leong Chew Melissa Gilbert-Ross
author_sort	Briana Rackley
title	The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
title_short	The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
title_full	The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
title_fullStr	The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
title_full_unstemmed	The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
title_sort	level of oncogenic ras determines the malignant transformation of lkb1 mutant tissue in vivo
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4b905d7cae645a3acc0a94273ef360d
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The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo

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