Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA

Abstract To evaluate the retinal vascular flow density changes of myopic eyes of young adults using optical coherence tomography angiography and the factors affecting these changes. In this cross-sectional study, 90 eyes of 45 participants were analyzed and divided into three groups: mild, moderate,...

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Autores principales:	Tiantian Wang, Hui Li, Rongrong Zhang, Yan Yu, Xin Xiao, Changfan Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4ba83e95e97465cac19a4d71c54980d
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spelling	oai:doaj.org-article:c4ba83e95e97465cac19a4d71c54980d2021-12-02T16:06:41ZEvaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA10.1038/s41598-021-94909-82045-2322https://doaj.org/article/c4ba83e95e97465cac19a4d71c54980d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94909-8https://doaj.org/toc/2045-2322Abstract To evaluate the retinal vascular flow density changes of myopic eyes of young adults using optical coherence tomography angiography and the factors affecting these changes. In this cross-sectional study, 90 eyes of 45 participants were analyzed and divided into three groups: mild, moderate, and high myopia (without pathological changes). Macular and radial peripapillary capillary flow densities were measured using optical coherence tomography angiography. Their relationships with the axial length, the spherical equivalent of the refractive error, and age were analyzed using analysis of variance, Pearson’s correlation coefficient, and multivariate linear regression analysis. Superficial and deep macular vascular densities were significantly decreased in the high myopia group compared to the other groups. In the high myopia group, the nasal peripapillary flow density decreased, whereas the flow density inside the disc increased. The axial length negatively correlated with the superficial and deep macular vascular density, but positively correlated with the vascular density inside the disc. The spherical equivalent of the refractive error negatively correlated with the macular vascular density. The retinal vascular density decreased in the high myopia group. Hence, the microvascular network inside the disc may have a compensatory action in the hypoxic setting of high myopia.Tiantian WangHui LiRongrong ZhangYan YuXin XiaoChangfan WuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiantian Wang Hui Li Rongrong Zhang Yan Yu Xin Xiao Changfan Wu Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
description	Abstract To evaluate the retinal vascular flow density changes of myopic eyes of young adults using optical coherence tomography angiography and the factors affecting these changes. In this cross-sectional study, 90 eyes of 45 participants were analyzed and divided into three groups: mild, moderate, and high myopia (without pathological changes). Macular and radial peripapillary capillary flow densities were measured using optical coherence tomography angiography. Their relationships with the axial length, the spherical equivalent of the refractive error, and age were analyzed using analysis of variance, Pearson’s correlation coefficient, and multivariate linear regression analysis. Superficial and deep macular vascular densities were significantly decreased in the high myopia group compared to the other groups. In the high myopia group, the nasal peripapillary flow density decreased, whereas the flow density inside the disc increased. The axial length negatively correlated with the superficial and deep macular vascular density, but positively correlated with the vascular density inside the disc. The spherical equivalent of the refractive error negatively correlated with the macular vascular density. The retinal vascular density decreased in the high myopia group. Hence, the microvascular network inside the disc may have a compensatory action in the hypoxic setting of high myopia.
format	article
author	Tiantian Wang Hui Li Rongrong Zhang Yan Yu Xin Xiao Changfan Wu
author_facet	Tiantian Wang Hui Li Rongrong Zhang Yan Yu Xin Xiao Changfan Wu
author_sort	Tiantian Wang
title	Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
title_short	Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
title_full	Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
title_fullStr	Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
title_full_unstemmed	Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA
title_sort	evaluation of retinal vascular density and related factors in youth myopia without maculopathy using octa
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4ba83e95e97465cac19a4d71c54980d
work_keys_str_mv	AT tiantianwang evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta AT huili evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta AT rongrongzhang evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta AT yanyu evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta AT xinxiao evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta AT changfanwu evaluationofretinalvasculardensityandrelatedfactorsinyouthmyopiawithoutmaculopathyusingocta
_version_	1718384929626128384

Evaluation of retinal vascular density and related factors in youth myopia without maculopathy using OCTA

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