Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance

Angela F Caveney1, Bruno Giordani1, George M Haig21Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; 2Neurosciences Development, Abbott Laboratories, Abbott Park, IL, USAAbstract: Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studi...

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Autores principales:	Angela F Caveney, Bruno Giordani, George M Haig
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c4bcebc9ea8046a1b52dcb41b0ece3fe
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spelling	oai:doaj.org-article:c4bcebc9ea8046a1b52dcb41b0ece3fe2021-12-02T07:20:15ZPreliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance1176-63281178-2021https://doaj.org/article/c4bcebc9ea8046a1b52dcb41b0ece3fe2008-03-01T00:00:00Zhttp://www.dovepress.com/preliminary-effects-of-pagoclone-a-partial-gabaa-agonist-on-neuropsych-a1009https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Angela F Caveney1, Bruno Giordani1, George M Haig21Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; 2Neurosciences Development, Abbott Laboratories, Abbott Park, IL, USAAbstract: Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studies suggest that pagoclone may have clinical utility as an anxiolytic agent, as well as a reduced incidence of side-effects. The present study was conducted to determine whether pagoclone would affect healthy individuals&rsquo; performances on neuropsychological measures as a function of dose within the projected therapeutic range. Twelve healthy adult subjects were randomly assigned to dosage groups in a 3-way crossover study. Participants were administered neuropsychological measures six hours following dosing on Day 1 and Day 6 of administration of the drug. Dose effects were noted on measures of alertness, learning, and memory and movement time. Significant effects were also noted on measures of alertness, learning and memory, information processing and psychomotor speed. Overall, the results of this small, preliminary study do not support a finding of behavioral toxicity for these doses of pagoclone. Rather, a pattern was found of transient and mild negative effects on learning and memory scores at the highest dose administered, though these changes were small and no longer evident by the sixth day of use.Keywords: pagoclone, cyclopyrrolone, neuropsychological, memory, generalized anxiety disorder Angela F CaveneyBruno GiordaniGeorge M HaigDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 277-282 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Angela F Caveney Bruno Giordani George M Haig Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
description	Angela F Caveney1, Bruno Giordani1, George M Haig21Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA; 2Neurosciences Development, Abbott Laboratories, Abbott Park, IL, USAAbstract: Pagoclone is a novel cyclopyrrolone that acts as a partial GABAA receptor agonist. Preclinical studies suggest that pagoclone may have clinical utility as an anxiolytic agent, as well as a reduced incidence of side-effects. The present study was conducted to determine whether pagoclone would affect healthy individuals&rsquo; performances on neuropsychological measures as a function of dose within the projected therapeutic range. Twelve healthy adult subjects were randomly assigned to dosage groups in a 3-way crossover study. Participants were administered neuropsychological measures six hours following dosing on Day 1 and Day 6 of administration of the drug. Dose effects were noted on measures of alertness, learning, and memory and movement time. Significant effects were also noted on measures of alertness, learning and memory, information processing and psychomotor speed. Overall, the results of this small, preliminary study do not support a finding of behavioral toxicity for these doses of pagoclone. Rather, a pattern was found of transient and mild negative effects on learning and memory scores at the highest dose administered, though these changes were small and no longer evident by the sixth day of use.Keywords: pagoclone, cyclopyrrolone, neuropsychological, memory, generalized anxiety disorder
format	article
author	Angela F Caveney Bruno Giordani George M Haig
author_facet	Angela F Caveney Bruno Giordani George M Haig
author_sort	Angela F Caveney
title	Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
title_short	Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
title_full	Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
title_fullStr	Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
title_full_unstemmed	Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance
title_sort	preliminary effects of pagoclone, a partial gabaa agonist, on neuropsychological performance
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/c4bcebc9ea8046a1b52dcb41b0ece3fe
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Preliminary effects of pagoclone, a partial GABAA agonist, on neuropsychological performance

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