Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography

Abstract Optical coherence tomography (OCT) angiography (OCTA) is a non-invasive tool for the in-vivo study of the intraretinal vascular network. It is based on the analysis of motion particles within the retina to reconstruct the paths followed by the erythrocytes, i.e. retinal capillaries. To date...

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Autores principales:	Alessandro Arrigo, Cristian Perra, Emanuela Aragona, Daniele Giusto, Francesco Bandello, Maurizio Battaglia Parodi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4bd781903514066ae43c1ec08a0eae0
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spelling	oai:doaj.org-article:c4bd781903514066ae43c1ec08a0eae02021-12-02T16:56:09ZTotal flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography10.1038/s41598-021-88681-y2045-2322https://doaj.org/article/c4bd781903514066ae43c1ec08a0eae02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88681-yhttps://doaj.org/toc/2045-2322Abstract Optical coherence tomography (OCT) angiography (OCTA) is a non-invasive tool for the in-vivo study of the intraretinal vascular network. It is based on the analysis of motion particles within the retina to reconstruct the paths followed by the erythrocytes, i.e. retinal capillaries. To date, qualitative and quantitative information are based on the morphological features disclosed by retinal capillaries. In the present study, we proposed new quantitative functional metrics, named Total Flow Intensity (TFI), Active Flow Intensity (AFI), and Volume-related Flow Intensity (VFI), based on the processing of the blood flow signal detected by OCTA. We studied these metrics in a cohort of healthy subjects, and we assessed their clinical utility by including a cohort of age-matched patients affected by Stargardt disease. Moreover, we compared TFI, AFI, and VFI to the widely used vessel density (VD) parameter. TFI, AFI, and VFI were able to describe in detail the different properties of the retinal vascular compartment. In particular, TFI was intended as the overall amount of volumetric retinal blood flow. AFI represented a selective measure of voxels disclosing blood flow signal. VFI was developed to put in relationship the volumetric blood flow information with the not vascularized retinal volume. In conclusion, TFI, AFI, and VFI were proposed as feasible functional OCTA biomarkers based on the analysis of retinal blood flow signal.Alessandro ArrigoCristian PerraEmanuela AragonaDaniele GiustoFrancesco BandelloMaurizio Battaglia ParodiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alessandro Arrigo Cristian Perra Emanuela Aragona Daniele Giusto Francesco Bandello Maurizio Battaglia Parodi Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
description	Abstract Optical coherence tomography (OCT) angiography (OCTA) is a non-invasive tool for the in-vivo study of the intraretinal vascular network. It is based on the analysis of motion particles within the retina to reconstruct the paths followed by the erythrocytes, i.e. retinal capillaries. To date, qualitative and quantitative information are based on the morphological features disclosed by retinal capillaries. In the present study, we proposed new quantitative functional metrics, named Total Flow Intensity (TFI), Active Flow Intensity (AFI), and Volume-related Flow Intensity (VFI), based on the processing of the blood flow signal detected by OCTA. We studied these metrics in a cohort of healthy subjects, and we assessed their clinical utility by including a cohort of age-matched patients affected by Stargardt disease. Moreover, we compared TFI, AFI, and VFI to the widely used vessel density (VD) parameter. TFI, AFI, and VFI were able to describe in detail the different properties of the retinal vascular compartment. In particular, TFI was intended as the overall amount of volumetric retinal blood flow. AFI represented a selective measure of voxels disclosing blood flow signal. VFI was developed to put in relationship the volumetric blood flow information with the not vascularized retinal volume. In conclusion, TFI, AFI, and VFI were proposed as feasible functional OCTA biomarkers based on the analysis of retinal blood flow signal.
format	article
author	Alessandro Arrigo Cristian Perra Emanuela Aragona Daniele Giusto Francesco Bandello Maurizio Battaglia Parodi
author_facet	Alessandro Arrigo Cristian Perra Emanuela Aragona Daniele Giusto Francesco Bandello Maurizio Battaglia Parodi
author_sort	Alessandro Arrigo
title	Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
title_short	Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
title_full	Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
title_fullStr	Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
title_full_unstemmed	Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
title_sort	total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4bd781903514066ae43c1ec08a0eae0
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Total flow intensity, active flow intensity and volume related flow intensity as new quantitative metrics in optical coherence tomography angiography

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