Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography

Abstract Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are autoimmune demyelinating diseases of distinct etiology presenting with optic neuritis (ON). This study aimed to identify the macular and peripapillary neurovascular alterations that may facilitate the differentia...

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Autores principales:	Małgorzata Rogaczewska, Sławomir Michalak, Marcin Stopa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c4bf50cfe9c64b4fb36bccc1dde2e395
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spelling	oai:doaj.org-article:c4bf50cfe9c64b4fb36bccc1dde2e3952021-12-02T16:51:14ZDifferentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography10.1038/s41598-021-90036-62045-2322https://doaj.org/article/c4bf50cfe9c64b4fb36bccc1dde2e3952021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90036-6https://doaj.org/toc/2045-2322Abstract Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are autoimmune demyelinating diseases of distinct etiology presenting with optic neuritis (ON). This study aimed to identify the macular and peripapillary neurovascular alterations that may facilitate the differentiation between NMOSD and MS eyes using spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA). A total of 13 NMOSD patients and 40 MS patients were evaluated. After ON, the radial peripapillary capillary (RPC) vessel density was significantly decreased in the superior (S) and inferior (I) sectors in NMOSD compared with MS eyes, whereas in non-ON eyes, the temporal (T) sector of RPC was reduced in MS group. In the ON eyes, the retinal nerve fiber layer in the I and T quadrants was thinner in NMOSD than in MS. Regarding ON and non-ON eyes, the macular capillary plexuses, and the ganglion cell complex thickness did not differ between NMOSD and MS. The ratios, based on the disease-specific intra-eye RPC vessel density reduction pattern, were the best discriminants between NMOSD and MS, i.e., inferior to nasal (I/N) and I/T ratios for ON eyes, and S/T and N/T ratios for non-ON eyes. Our results show that the OCTA-based simple ratios may be useful in distinguishing NMOSD and MS patients.Małgorzata RogaczewskaSławomir MichalakMarcin StopaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Małgorzata Rogaczewska Sławomir Michalak Marcin Stopa Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
description	Abstract Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are autoimmune demyelinating diseases of distinct etiology presenting with optic neuritis (ON). This study aimed to identify the macular and peripapillary neurovascular alterations that may facilitate the differentiation between NMOSD and MS eyes using spectral-domain optical coherence tomography (OCT) and OCT angiography (OCTA). A total of 13 NMOSD patients and 40 MS patients were evaluated. After ON, the radial peripapillary capillary (RPC) vessel density was significantly decreased in the superior (S) and inferior (I) sectors in NMOSD compared with MS eyes, whereas in non-ON eyes, the temporal (T) sector of RPC was reduced in MS group. In the ON eyes, the retinal nerve fiber layer in the I and T quadrants was thinner in NMOSD than in MS. Regarding ON and non-ON eyes, the macular capillary plexuses, and the ganglion cell complex thickness did not differ between NMOSD and MS. The ratios, based on the disease-specific intra-eye RPC vessel density reduction pattern, were the best discriminants between NMOSD and MS, i.e., inferior to nasal (I/N) and I/T ratios for ON eyes, and S/T and N/T ratios for non-ON eyes. Our results show that the OCTA-based simple ratios may be useful in distinguishing NMOSD and MS patients.
format	article
author	Małgorzata Rogaczewska Sławomir Michalak Marcin Stopa
author_facet	Małgorzata Rogaczewska Sławomir Michalak Marcin Stopa
author_sort	Małgorzata Rogaczewska
title	Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
title_short	Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
title_full	Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
title_fullStr	Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
title_full_unstemmed	Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
title_sort	differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c4bf50cfe9c64b4fb36bccc1dde2e395
work_keys_str_mv	AT małgorzatarogaczewska differentiationbetweenmultiplesclerosisandneuromyelitisopticaspectrumdisorderusingopticalcoherencetomographyangiography AT sławomirmichalak differentiationbetweenmultiplesclerosisandneuromyelitisopticaspectrumdisorderusingopticalcoherencetomographyangiography AT marcinstopa differentiationbetweenmultiplesclerosisandneuromyelitisopticaspectrumdisorderusingopticalcoherencetomographyangiography
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Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorder using optical coherence tomography angiography

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