CD4-positive lymphoepithelial-like carcinoma: Report of unusual case

We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrat...

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Autores principales:	Luaay Aziz, Raya Saab, Toufic Eid, Mousa A Al-Abbadi
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2018
Materias:	cd4 epstein–bar virus lymphoepithelial-like carcinoma nasopharyngeal carcinoma Medicine R
Acceso en línea:	https://doaj.org/article/c4c2539858dc44818824f0df9b6b44e3
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spelling	oai:doaj.org-article:c4c2539858dc44818824f0df9b6b44e32021-12-02T16:35:54ZCD4-positive lymphoepithelial-like carcinoma: Report of unusual case2231-07702249-446410.4103/ajm.AJM_135_17https://doaj.org/article/c4c2539858dc44818824f0df9b6b44e32018-04-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.4103/ajm.AJM_135_17https://doaj.org/toc/2231-0770https://doaj.org/toc/2249-4464We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein–Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein–Bar virus-associated nasopharyngeal carcinoma with excellent response.Luaay AzizRaya SaabToufic EidMousa A Al-AbbadiThieme Medical and Scientific Publishers Pvt. Ltd.articlecd4epstein–bar viruslymphoepithelial-like carcinomanasopharyngeal carcinomaMedicineRENAvicenna Journal of Medicine, Vol 8, Iss 02, Pp 58-62 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cd4 epstein–bar virus lymphoepithelial-like carcinoma nasopharyngeal carcinoma Medicine R
spellingShingle	cd4 epstein–bar virus lymphoepithelial-like carcinoma nasopharyngeal carcinoma Medicine R Luaay Aziz Raya Saab Toufic Eid Mousa A Al-Abbadi CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
description	We are reporting an unusual case of lymphoepithelial-like carcinoma (LELC) in an 8-year-old female patient where the tumor cells showed unusual CD4 expression. The lesion was found in the left submandibular neck region, in the vicinity of the submandibular gland. The salivary gland was not infiltrated by the tumor, and the tumor exhibited a classic LELC with single and clusters of tumor cells surrounded by many hematolymphoid cells. The tumor cells revealed strong positivity for Epstein–Bar virus as confirmed by the EBER: Epstein-Barr Virus in situ hybridization (EBER-ISH) method of staining. Interestingly, the tumor cells expressed membranous immunostaining for the T-helper lymphocyte antibody (CD4) in addition to pan-cytokeratin. A brief discussion about this unusual finding is offered. The patient was treated as a case of Epstein–Bar virus-associated nasopharyngeal carcinoma with excellent response.
format	article
author	Luaay Aziz Raya Saab Toufic Eid Mousa A Al-Abbadi
author_facet	Luaay Aziz Raya Saab Toufic Eid Mousa A Al-Abbadi
author_sort	Luaay Aziz
title	CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
title_short	CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
title_full	CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
title_fullStr	CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
title_full_unstemmed	CD4-positive lymphoepithelial-like carcinoma: Report of unusual case
title_sort	cd4-positive lymphoepithelial-like carcinoma: report of unusual case
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2018
url	https://doaj.org/article/c4c2539858dc44818824f0df9b6b44e3
work_keys_str_mv	AT luaayaziz cd4positivelymphoepitheliallikecarcinomareportofunusualcase AT rayasaab cd4positivelymphoepitheliallikecarcinomareportofunusualcase AT touficeid cd4positivelymphoepitheliallikecarcinomareportofunusualcase AT mousaaalabbadi cd4positivelymphoepitheliallikecarcinomareportofunusualcase
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CD4-positive lymphoepithelial-like carcinoma: Report of unusual case

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